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Mechanistic Insights into Harmine-Mediated Inhibition of Human DNA Methyltransferases and Prostate Cancer Cell Growth

[Image: see text] Mammalian DNA methyltransferases (DNMTs), including DNMT1, DNMT3A, and DNMT3B, are key DNA methylation enzymes and play important roles in gene expression regulation. Dysregulation of DNMTs is linked to various diseases and carcinogenesis, and therefore except for the two approved...

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Detalles Bibliográficos
Autores principales:	Cho, Chao-Cheng, Lin, Chun-Jung, Huang, Hsun-Ho, Yang, Wei-Zen, Fei, Cheng-Yin, Lin, Hsin-Ying, Lee, Ming-Shyue, Yuan, Hanna S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278071/ https://www.ncbi.nlm.nih.gov/pubmed/37188336 http://dx.doi.org/10.1021/acschembio.3c00065

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