Cargando…

Mechanistic Insights into Harmine-Mediated Inhibition of Human DNA Methyltransferases and Prostate Cancer Cell Growth

[Image: see text] Mammalian DNA methyltransferases (DNMTs), including DNMT1, DNMT3A, and DNMT3B, are key DNA methylation enzymes and play important roles in gene expression regulation. Dysregulation of DNMTs is linked to various diseases and carcinogenesis, and therefore except for the two approved...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cho, Chao-Cheng, Lin, Chun-Jung, Huang, Hsun-Ho, Yang, Wei-Zen, Fei, Cheng-Yin, Lin, Hsin-Ying, Lee, Ming-Shyue, Yuan, Hanna S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278071/ https://www.ncbi.nlm.nih.gov/pubmed/37188336 http://dx.doi.org/10.1021/acschembio.3c00065

Ejemplares similares

Mechanistic Insights on the Inhibition of C5 DNA Methyltransferases by Zebularine
por: Champion, Christine, et al.
Publicado: (2010)

Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B
por: Lin, Chien-Chu, et al.
Publicado: (2020)

Binding of Harmine Derivatives to DNA: A Spectroscopic Investigation
por: Pagano, Bruno, et al.
Publicado: (2017)

Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity
por: Lee, Yi-Ru, et al.
Publicado: (2016)

Novel harmine derivatives for tumor targeted therapy
por: Li, Siwen, et al.
Publicado: (2015)

Harmine stimulates proliferation of human neural progenitors
por: Dakic, Vanja, et al.
Publicado: (2016)

Harmine targets inhibitor of DNA binding‐2 and activator protein‐1 to promote preosteoclast PDGF‐BB production
por: Huang, Jie, et al.
Publicado: (2021)

Liposomes coated with N-trimethyl chitosan to improve the absorption of harmine in vivo and in vitro
por: Chen, Wei-liang, et al.
Publicado: (2016)

Potential Antitumor Effect of Harmine in the Treatment of Thyroid Cancer
por: Ruan, Shu, et al.
Publicado: (2017)

Harmine Acts as an Indirect Inhibitor of Intracellular Protein Aggregation
por: Jain, Swati, et al.
Publicado: (2020)

Synthesis and mechanisms of action of novel harmine derivatives as potential antitumor agents
por: Zhang, Xiao-Fei, et al.
Publicado: (2016)

Mechanistic Insights into the Allosteric Regulation of the Clr4 Protein Lysine Methyltransferase by Autoinhibition and Automethylation
por: Khella, Mina S., et al.
Publicado: (2020)

Application of the central composite design to optimize the preparation of novel micelles of harmine
por: Bei, Yong-Yan, et al.
Publicado: (2013)

Harmine enhances type H vessel formation and prevents bone loss in ovariectomized mice
por: Huang, Jie, et al.
Publicado: (2018)

Harmine and Imipramine Promote Antioxidant Activities in Prefrontal Cortex and Hippocampus
por: Réus, Gislaine Z., et al.
Publicado: (2010)

Effect of Harmine on Nicotine-Induced Kidney Dysfunction in Male Mice
por: Salahshoor, Mohammad Reza, et al.
Publicado: (2019)

Harmine and Piperlongumine Revert TRIB2-Mediated Drug Resistance
por: Machado, Susana, et al.
Publicado: (2020)

Innovative spectrofluorometric method for determination of harmaline and harmine in different matrices
por: Abdelazim, Ahmed H., et al.
Publicado: (2023)

Harmine suppresses the proliferation of pancreatic cancer cells and sensitizes pancreatic cancer to gemcitabine treatment
por: Wu, Lin-Wen, et al.
Publicado: (2019)

A screening identifies harmine as a novel antibacterial compound against Ralstonia solanacearum
por: Xia, Hongkai, et al.
Publicado: (2023)

Convergent Mechanistic Features between the Structurally Diverse N- and O-Methyltransferases: Glycine N-Methyltransferase and Catechol O-Methyltransferase
por: Zhang, Jianyu, et al.
Publicado: (2016)

Mechanistic Insights into the Link between Obesity and Prostate Cancer
por: Adesunloye, Bamidele A.
Publicado: (2021)

Harmicens, Novel Harmine and Ferrocene Hybrids: Design, Synthesis and Biological Activity
por: Poje, Goran, et al.
Publicado: (2022)

In vitro and in vivo Efficacies of Novel Harmine Derivatives in the Treatment of Cystic Echinococcosis
por: Chen, Bei, et al.
Publicado: (2023)

Harmine reinforces the effects of regorafenib on suppressing cell proliferation and inducing apoptosis in liver cancer cells
por: Chen, Zi-Yi, et al.
Publicado: (2022)

Indolethylamine-N-Methyltransferase Inhibits Proliferation and Promotes Apoptosis of Human Prostate Cancer Cells: A Mechanistic Exploration
por: Jianfeng, Wang, et al.
Publicado: (2022)

Development of a universal radioactive DNA methyltransferase inhibition test for high-throughput screening and mechanistic studies
por: Gros, Christina, et al.
Publicado: (2013)

Effect of MAOA DNA Methylation on Human in Vivo Protein Expression Measured by [(11)C]harmine Positron Emission Tomography
por: Handschuh, Patricia A, et al.
Publicado: (2022)

Therapeutic Potential of Marine Peptides in Prostate Cancer: Mechanistic Insights
por: Ahmed, Salman, et al.
Publicado: (2022)

Harmine induces anticancer activity in breast cancer cells via targeting TAZ
por: Ding, Yu, et al.
Publicado: (2019)

Harmine, an inhibitor of the type III secretion system of Salmonella enterica serovar Typhimurium
por: Shi, Yunjia, et al.
Publicado: (2022)

Harmine suppresses the malignant phenotypes and PI3K activity in breast cancer
por: Yao, Pengmei, et al.
Publicado: (2022)

Analogous β-Carboline Alkaloids Harmaline and Harmine Ameliorate Scopolamine-Induced Cognition Dysfunction by Attenuating Acetylcholinesterase Activity, Oxidative Stress, and Inflammation in Mice
por: Li, Shu-Ping, et al.
Publicado: (2018)

Theoretical Insights into Catalytic Mechanism of Protein Arginine Methyltransferase 1
por: Zhang, Ruihan, et al.
Publicado: (2013)

New Insights on the Mechanism of Quinoline-based DNA Methyltransferase Inhibitors
por: Gros, Christina, et al.
Publicado: (2015)

Autophagy and Diabetic Encephalopathy: Mechanistic Insights and Potential Therapeutic Implications
por: Cheng, Li-zhen, et al.
Publicado: (2022)

Mechanistic insight into ligand binding to G-quadruplex DNA
por: Di Leva, Francesco Saverio, et al.
Publicado: (2014)

Mechanistic insights into Lhr helicase function in DNA repair
por: Buckley, Ryan J., et al.
Publicado: (2020)

Exposure Characteristics of the Analogous β-Carboline Alkaloids Harmaline and Harmine Based on the Efflux Transporter of Multidrug Resistance Protein 2
por: Li, Shuping, et al.
Publicado: (2017)

Dynamic Changes of Endogenic or Exogenic β-Carboline Alkaloid Harmine in Different Mammals and Human in vivo at Developmental and Physiological States
por: Cao, Ning, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ak1cdt65ms6ra8m0qoere28lqg