Going Full Circle with Organocatalysis and Biocatalysis: The Latent Potential of Cofactor Mimics in Asymmetric Synthesis

[Image: see text] Many enzymes work in tandem with small molecule cofactors, which have inspired organocatalyst designs. Chemical modification of cofactor scaffolds has increased organocatalytic reactivity and reaction scope. This synopsis presents a selection of recent advances in the use of cofact...

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Autores principales: Murray, Jacob, Hodgson, David R. W., O’Donoghue, AnnMarie C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278144/
https://www.ncbi.nlm.nih.gov/pubmed/37126859
http://dx.doi.org/10.1021/acs.joc.2c02747
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author Murray, Jacob
Hodgson, David R. W.
O’Donoghue, AnnMarie C.
author_facet Murray, Jacob
Hodgson, David R. W.
O’Donoghue, AnnMarie C.
author_sort Murray, Jacob
collection PubMed
description [Image: see text] Many enzymes work in tandem with small molecule cofactors, which have inspired organocatalyst designs. Chemical modification of cofactor scaffolds has increased organocatalytic reactivity and reaction scope. This synopsis presents a selection of recent advances in the use of cofactors (native and mimics) in organocatalysis and biocatalysis. We aim to highlight the benefits of combining fundamental knowledge gained in both bio- and organo-catalysis for asymmetric biocatalysis.
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spelling pubmed-102781442023-06-20 Going Full Circle with Organocatalysis and Biocatalysis: The Latent Potential of Cofactor Mimics in Asymmetric Synthesis Murray, Jacob Hodgson, David R. W. O’Donoghue, AnnMarie C. J Org Chem [Image: see text] Many enzymes work in tandem with small molecule cofactors, which have inspired organocatalyst designs. Chemical modification of cofactor scaffolds has increased organocatalytic reactivity and reaction scope. This synopsis presents a selection of recent advances in the use of cofactors (native and mimics) in organocatalysis and biocatalysis. We aim to highlight the benefits of combining fundamental knowledge gained in both bio- and organo-catalysis for asymmetric biocatalysis. American Chemical Society 2023-04-26 /pmc/articles/PMC10278144/ /pubmed/37126859 http://dx.doi.org/10.1021/acs.joc.2c02747 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Murray, Jacob
Hodgson, David R. W.
O’Donoghue, AnnMarie C.
Going Full Circle with Organocatalysis and Biocatalysis: The Latent Potential of Cofactor Mimics in Asymmetric Synthesis
title Going Full Circle with Organocatalysis and Biocatalysis: The Latent Potential of Cofactor Mimics in Asymmetric Synthesis
title_full Going Full Circle with Organocatalysis and Biocatalysis: The Latent Potential of Cofactor Mimics in Asymmetric Synthesis
title_fullStr Going Full Circle with Organocatalysis and Biocatalysis: The Latent Potential of Cofactor Mimics in Asymmetric Synthesis
title_full_unstemmed Going Full Circle with Organocatalysis and Biocatalysis: The Latent Potential of Cofactor Mimics in Asymmetric Synthesis
title_short Going Full Circle with Organocatalysis and Biocatalysis: The Latent Potential of Cofactor Mimics in Asymmetric Synthesis
title_sort going full circle with organocatalysis and biocatalysis: the latent potential of cofactor mimics in asymmetric synthesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278144/
https://www.ncbi.nlm.nih.gov/pubmed/37126859
http://dx.doi.org/10.1021/acs.joc.2c02747
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