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Clinical characteristics, management, and outcomes of patients with primary cardiac angiosarcoma: A systematic review

Primary cardiac angiosarcomas (PCA) are highly aggressive malignant heart tumors. Previous reports have shown a poor prognosis regardless of management, and no consensus or guidelines exist. It is necessary to clarify this information since patients with PCA have a short survival. Therefore, we aime...

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Autores principales: Chambergo-Michilot, Diego, De la Cruz-Ku, Gabriel, Sterner, Rosalie M., Brañez-Condorena, Ana, Guerra-Canchari, Pedro, Stulak, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tabriz University of Medical Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278191/
https://www.ncbi.nlm.nih.gov/pubmed/37342661
http://dx.doi.org/10.34172/jcvtr.2023.30531
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author Chambergo-Michilot, Diego
De la Cruz-Ku, Gabriel
Sterner, Rosalie M.
Brañez-Condorena, Ana
Guerra-Canchari, Pedro
Stulak, John
author_facet Chambergo-Michilot, Diego
De la Cruz-Ku, Gabriel
Sterner, Rosalie M.
Brañez-Condorena, Ana
Guerra-Canchari, Pedro
Stulak, John
author_sort Chambergo-Michilot, Diego
collection PubMed
description Primary cardiac angiosarcomas (PCA) are highly aggressive malignant heart tumors. Previous reports have shown a poor prognosis regardless of management, and no consensus or guidelines exist. It is necessary to clarify this information since patients with PCA have a short survival. Therefore, we aimed to systematically review clinical manifestations, management, and outcomes. We systematically searched in PubMed, Scopus, Web of Science, and EMBASE. We intended to include cross-sectional studies, case-control studies, cohort studies, and case series that reported clinical characteristics, management, and outcomes of patients with PCA. As a methodological approach, we used the Joanna Briggs Institute Critical Appraisal Checklist for Case Series and the Newcastle-Ottawa Scale for cohorts. We included six studies (five case series, one cohort). The mean/median age ranged from 39 to 48.9 years. Male sex was predominant. The most frequent manifestations were dyspnea (range: 50%-80%), pericardial effusion (29% & 56%), and chest pain (10%-39%). The mean tumor size ranged from 5.8 to 7.2 cm, with the majority of these localized in the right atrium (70-100%). The most common locations of metastasis were the lung (20%-55.6%), liver (10%-22.2%), and bone (10%-20%). Resection (22.9%-94%), and chemotherapy as neoadjuvant or adjuvant (30%-100%) were the most commonly used methods of treatment. Mortality ranged from 64.7% to 100%. PCA often presents late in its course and usually results in poor prognosis. We strongly recommend performing multi-institutional prospective cohorts to better study disease course and treatments to develop consensus, algorithms, and guidelines for this type of sarcoma.
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spelling pubmed-102781912023-06-20 Clinical characteristics, management, and outcomes of patients with primary cardiac angiosarcoma: A systematic review Chambergo-Michilot, Diego De la Cruz-Ku, Gabriel Sterner, Rosalie M. Brañez-Condorena, Ana Guerra-Canchari, Pedro Stulak, John J Cardiovasc Thorac Res Review Article Primary cardiac angiosarcomas (PCA) are highly aggressive malignant heart tumors. Previous reports have shown a poor prognosis regardless of management, and no consensus or guidelines exist. It is necessary to clarify this information since patients with PCA have a short survival. Therefore, we aimed to systematically review clinical manifestations, management, and outcomes. We systematically searched in PubMed, Scopus, Web of Science, and EMBASE. We intended to include cross-sectional studies, case-control studies, cohort studies, and case series that reported clinical characteristics, management, and outcomes of patients with PCA. As a methodological approach, we used the Joanna Briggs Institute Critical Appraisal Checklist for Case Series and the Newcastle-Ottawa Scale for cohorts. We included six studies (five case series, one cohort). The mean/median age ranged from 39 to 48.9 years. Male sex was predominant. The most frequent manifestations were dyspnea (range: 50%-80%), pericardial effusion (29% & 56%), and chest pain (10%-39%). The mean tumor size ranged from 5.8 to 7.2 cm, with the majority of these localized in the right atrium (70-100%). The most common locations of metastasis were the lung (20%-55.6%), liver (10%-22.2%), and bone (10%-20%). Resection (22.9%-94%), and chemotherapy as neoadjuvant or adjuvant (30%-100%) were the most commonly used methods of treatment. Mortality ranged from 64.7% to 100%. PCA often presents late in its course and usually results in poor prognosis. We strongly recommend performing multi-institutional prospective cohorts to better study disease course and treatments to develop consensus, algorithms, and guidelines for this type of sarcoma. Tabriz University of Medical Sciences 2023 2023-03-16 /pmc/articles/PMC10278191/ /pubmed/37342661 http://dx.doi.org/10.34172/jcvtr.2023.30531 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chambergo-Michilot, Diego
De la Cruz-Ku, Gabriel
Sterner, Rosalie M.
Brañez-Condorena, Ana
Guerra-Canchari, Pedro
Stulak, John
Clinical characteristics, management, and outcomes of patients with primary cardiac angiosarcoma: A systematic review
title Clinical characteristics, management, and outcomes of patients with primary cardiac angiosarcoma: A systematic review
title_full Clinical characteristics, management, and outcomes of patients with primary cardiac angiosarcoma: A systematic review
title_fullStr Clinical characteristics, management, and outcomes of patients with primary cardiac angiosarcoma: A systematic review
title_full_unstemmed Clinical characteristics, management, and outcomes of patients with primary cardiac angiosarcoma: A systematic review
title_short Clinical characteristics, management, and outcomes of patients with primary cardiac angiosarcoma: A systematic review
title_sort clinical characteristics, management, and outcomes of patients with primary cardiac angiosarcoma: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278191/
https://www.ncbi.nlm.nih.gov/pubmed/37342661
http://dx.doi.org/10.34172/jcvtr.2023.30531
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