Cargando…

Effectiveness of "Centaurea behen" root on quality of life in patients with systolic heart failure: A randomized clinical trial

Introduction: The effect of Centaurea behen (Cb) on patients with systolic heart failure is not known academically. This study was conducted to evaluate the effect of Cb on improving the quality of life (QoL) and echocardiographic and biochemical blood parameters in patients with systolic heart fail...

Descripción completa

Detalles Bibliográficos
Autores principales: Yousefi, Saeid, Ahangar, Hassan, Bahrami, Mohsen, Kamalinejad, Mohammad, Yaghoubi, Alireza, Azizi, Hosein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tabriz University of Medical Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278197/
https://www.ncbi.nlm.nih.gov/pubmed/37342665
http://dx.doi.org/10.34172/jcvtr.2023.31619
_version_ 1785060433068032000
author Yousefi, Saeid
Ahangar, Hassan
Bahrami, Mohsen
Kamalinejad, Mohammad
Yaghoubi, Alireza
Azizi, Hosein
author_facet Yousefi, Saeid
Ahangar, Hassan
Bahrami, Mohsen
Kamalinejad, Mohammad
Yaghoubi, Alireza
Azizi, Hosein
author_sort Yousefi, Saeid
collection PubMed
description Introduction: The effect of Centaurea behen (Cb) on patients with systolic heart failure is not known academically. This study was conducted to evaluate the effect of Cb on improving the quality of life (QoL) and echocardiographic and biochemical blood parameters in patients with systolic heart failure. Methods: This study was a parallel double-blind, placebo-controlled randomized trial of 60 patients with systolic heart failure, was conducted from May 2018 up to August 2019. Intervention group received 150 mg twice daily Cb capsules for two months + Guideline directed medical therapy (GDMT), and control group received GDMT + placebo capsules for two months. The main aim of the present study were to assess the QoL based on the 6-minute walk test (6MWT) and the Minnesota living with heart failure questionnaire (MLHFQ). Independent T-test, paired T-test, and ANOVA were used for the analysis. Results: At the beginning of the present study there were no significant differences between study groups in terms of QoL and clinical results. After treatment, the average values of QoL based on MLHFQ and 6MWT instruments were significantly improved 15.5 and 36.18, respectively (P<0.05). Conclusion: Based on the MLHFQ, and 6MWT tests, the consumption of Centaurea behen root extract was associated with significant improvement in the quality of life of patients with systolic heart failure.
format Online
Article
Text
id pubmed-10278197
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Tabriz University of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-102781972023-06-20 Effectiveness of "Centaurea behen" root on quality of life in patients with systolic heart failure: A randomized clinical trial Yousefi, Saeid Ahangar, Hassan Bahrami, Mohsen Kamalinejad, Mohammad Yaghoubi, Alireza Azizi, Hosein J Cardiovasc Thorac Res Original Article Introduction: The effect of Centaurea behen (Cb) on patients with systolic heart failure is not known academically. This study was conducted to evaluate the effect of Cb on improving the quality of life (QoL) and echocardiographic and biochemical blood parameters in patients with systolic heart failure. Methods: This study was a parallel double-blind, placebo-controlled randomized trial of 60 patients with systolic heart failure, was conducted from May 2018 up to August 2019. Intervention group received 150 mg twice daily Cb capsules for two months + Guideline directed medical therapy (GDMT), and control group received GDMT + placebo capsules for two months. The main aim of the present study were to assess the QoL based on the 6-minute walk test (6MWT) and the Minnesota living with heart failure questionnaire (MLHFQ). Independent T-test, paired T-test, and ANOVA were used for the analysis. Results: At the beginning of the present study there were no significant differences between study groups in terms of QoL and clinical results. After treatment, the average values of QoL based on MLHFQ and 6MWT instruments were significantly improved 15.5 and 36.18, respectively (P<0.05). Conclusion: Based on the MLHFQ, and 6MWT tests, the consumption of Centaurea behen root extract was associated with significant improvement in the quality of life of patients with systolic heart failure. Tabriz University of Medical Sciences 2023 2023-03-16 /pmc/articles/PMC10278197/ /pubmed/37342665 http://dx.doi.org/10.34172/jcvtr.2023.31619 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yousefi, Saeid
Ahangar, Hassan
Bahrami, Mohsen
Kamalinejad, Mohammad
Yaghoubi, Alireza
Azizi, Hosein
Effectiveness of "Centaurea behen" root on quality of life in patients with systolic heart failure: A randomized clinical trial
title Effectiveness of "Centaurea behen" root on quality of life in patients with systolic heart failure: A randomized clinical trial
title_full Effectiveness of "Centaurea behen" root on quality of life in patients with systolic heart failure: A randomized clinical trial
title_fullStr Effectiveness of "Centaurea behen" root on quality of life in patients with systolic heart failure: A randomized clinical trial
title_full_unstemmed Effectiveness of "Centaurea behen" root on quality of life in patients with systolic heart failure: A randomized clinical trial
title_short Effectiveness of "Centaurea behen" root on quality of life in patients with systolic heart failure: A randomized clinical trial
title_sort effectiveness of "centaurea behen" root on quality of life in patients with systolic heart failure: a randomized clinical trial
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278197/
https://www.ncbi.nlm.nih.gov/pubmed/37342665
http://dx.doi.org/10.34172/jcvtr.2023.31619
work_keys_str_mv AT yousefisaeid effectivenessofcentaureabehenrootonqualityoflifeinpatientswithsystolicheartfailurearandomizedclinicaltrial
AT ahangarhassan effectivenessofcentaureabehenrootonqualityoflifeinpatientswithsystolicheartfailurearandomizedclinicaltrial
AT bahramimohsen effectivenessofcentaureabehenrootonqualityoflifeinpatientswithsystolicheartfailurearandomizedclinicaltrial
AT kamalinejadmohammad effectivenessofcentaureabehenrootonqualityoflifeinpatientswithsystolicheartfailurearandomizedclinicaltrial
AT yaghoubialireza effectivenessofcentaureabehenrootonqualityoflifeinpatientswithsystolicheartfailurearandomizedclinicaltrial
AT azizihosein effectivenessofcentaureabehenrootonqualityoflifeinpatientswithsystolicheartfailurearandomizedclinicaltrial