Lipid kinase PIP5Kα contributes to Hippo pathway activation via interaction with Merlin and by mediating plasma membrane targeting of LATS1

BACKGROUND: The Hippo pathway plays a critical role in controlled cell proliferation. The tumor suppressor Merlin and large tumor suppressor kinase 1 (LATS1) mediate activation of Hippo pathway, consequently inhibiting the primary effectors, Yes-associated protein (YAP) and transcriptional coactivat...

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Detalles Bibliográficos
Autores principales: Le, Truc Phan Hoang, Nguyen, Nga Thi Thanh, Le, Duong Duy Thai, Anwar, Muhammad Ayaz, Lee, Sang Yoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278285/
https://www.ncbi.nlm.nih.gov/pubmed/37337213
http://dx.doi.org/10.1186/s12964-023-01161-w

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