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Efficacy of fibroblast transplantation in the healing of cutaneous leishmaniasis scar: A case report
Autologous fibroblast transplantation has been proven to be a promising method in wound healing with no side effects. This is the first study aimed to determine the efficacy and safety of autologous fibroblast cell injection to the atrophic scar caused by cutaneous leishmaniasis as an endemic diseas...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278424/ https://www.ncbi.nlm.nih.gov/pubmed/37342423 http://dx.doi.org/10.1177/2050313X231181171 |
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author | Faghihi, Faezeh Larijani, Ghazaleh Mohebbi, Lena Ketabforoush, Arsh Haj Mohamad Ebrahim Amini, Naser Mardasi, Kimiya Ghanbari |
author_facet | Faghihi, Faezeh Larijani, Ghazaleh Mohebbi, Lena Ketabforoush, Arsh Haj Mohamad Ebrahim Amini, Naser Mardasi, Kimiya Ghanbari |
author_sort | Faghihi, Faezeh |
collection | PubMed |
description | Autologous fibroblast transplantation has been proven to be a promising method in wound healing with no side effects. This is the first study aimed to determine the efficacy and safety of autologous fibroblast cell injection to the atrophic scar caused by cutaneous leishmaniasis as an endemic disease in many middle-eastern countries. It causes chronic skin lesions and permanently disfiguring scars. Autologous fibroblasts were obtained from the patient’s ear skin and were injected intradermally twice at 2-month intervals. Outcomes were measured using ultrasonography, VisioFace, and Cutometer. No adverse reaction was observed. The results showed improvements in epidermal thickness and density, melanin level, and skin lightening. Moreover, the skin elasticity in the scar area increased after the second transplantation. No improvement was observed in dermal thickness and density. A longer follow-up with more patients is recommended to investigate the effectiveness of fibroblast transplantation better. |
format | Online Article Text |
id | pubmed-10278424 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-102784242023-06-20 Efficacy of fibroblast transplantation in the healing of cutaneous leishmaniasis scar: A case report Faghihi, Faezeh Larijani, Ghazaleh Mohebbi, Lena Ketabforoush, Arsh Haj Mohamad Ebrahim Amini, Naser Mardasi, Kimiya Ghanbari SAGE Open Med Case Rep JCMS Case Report Autologous fibroblast transplantation has been proven to be a promising method in wound healing with no side effects. This is the first study aimed to determine the efficacy and safety of autologous fibroblast cell injection to the atrophic scar caused by cutaneous leishmaniasis as an endemic disease in many middle-eastern countries. It causes chronic skin lesions and permanently disfiguring scars. Autologous fibroblasts were obtained from the patient’s ear skin and were injected intradermally twice at 2-month intervals. Outcomes were measured using ultrasonography, VisioFace, and Cutometer. No adverse reaction was observed. The results showed improvements in epidermal thickness and density, melanin level, and skin lightening. Moreover, the skin elasticity in the scar area increased after the second transplantation. No improvement was observed in dermal thickness and density. A longer follow-up with more patients is recommended to investigate the effectiveness of fibroblast transplantation better. SAGE Publications 2023-06-16 /pmc/articles/PMC10278424/ /pubmed/37342423 http://dx.doi.org/10.1177/2050313X231181171 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | JCMS Case Report Faghihi, Faezeh Larijani, Ghazaleh Mohebbi, Lena Ketabforoush, Arsh Haj Mohamad Ebrahim Amini, Naser Mardasi, Kimiya Ghanbari Efficacy of fibroblast transplantation in the healing of cutaneous leishmaniasis scar: A case report |
title | Efficacy of fibroblast transplantation in the healing of cutaneous leishmaniasis scar: A case report |
title_full | Efficacy of fibroblast transplantation in the healing of cutaneous leishmaniasis scar: A case report |
title_fullStr | Efficacy of fibroblast transplantation in the healing of cutaneous leishmaniasis scar: A case report |
title_full_unstemmed | Efficacy of fibroblast transplantation in the healing of cutaneous leishmaniasis scar: A case report |
title_short | Efficacy of fibroblast transplantation in the healing of cutaneous leishmaniasis scar: A case report |
title_sort | efficacy of fibroblast transplantation in the healing of cutaneous leishmaniasis scar: a case report |
topic | JCMS Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278424/ https://www.ncbi.nlm.nih.gov/pubmed/37342423 http://dx.doi.org/10.1177/2050313X231181171 |
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