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Effect of co‐medications and potential risk factors of high‐dose methotrexate‐mediated acute hepatotoxicity in patients with osteosarcoma

BACKGROUND: Taiwanese patients frequently experience severe hepatotoxicity associated with high‐dose methotrexate (HD‐MTX) treatment, which interferes with subsequent treatment. Drug–drug interactions occur when MTX is used in combination with proton pump inhibitors (PPIs), trimethoprim‐sulfamethoxa...

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Detalles Bibliográficos
Autores principales:	Wang, Sheng‐Fan, Huang, Kuan‐Wei, Chou, Yueh‐Ching, Lee, Hsin‐Chen, Wu, Po‐Kuei, Chen, Wei‐Ming, Hung, Giun‐Yi, Chang, Yuh‐Lih
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	RESEARCH ARTICLES
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278458/ https://www.ncbi.nlm.nih.gov/pubmed/37062070 http://dx.doi.org/10.1002/cam4.5936

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