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ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature

Some patients remain unwell for months after “recovering” from acute COVID-19. They develop persistent fatigue, cognitive problems, headaches, disrupted sleep, myalgias and arthralgias, post-exertional malaise, orthostatic intolerance and other symptoms that greatly interfere with their ability to f...

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Detalles Bibliográficos
Autores principales: Komaroff, Anthony L., Lipkin, W. Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278546/
https://www.ncbi.nlm.nih.gov/pubmed/37342500
http://dx.doi.org/10.3389/fmed.2023.1187163
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author Komaroff, Anthony L.
Lipkin, W. Ian
author_facet Komaroff, Anthony L.
Lipkin, W. Ian
author_sort Komaroff, Anthony L.
collection PubMed
description Some patients remain unwell for months after “recovering” from acute COVID-19. They develop persistent fatigue, cognitive problems, headaches, disrupted sleep, myalgias and arthralgias, post-exertional malaise, orthostatic intolerance and other symptoms that greatly interfere with their ability to function and that can leave some people housebound and disabled. The illness (Long COVID) is similar to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) as well as to persisting illnesses that can follow a wide variety of other infectious agents and following major traumatic injury. Together, these illnesses are projected to cost the U.S. trillions of dollars. In this review, we first compare the symptoms of ME/CFS and Long COVID, noting the considerable similarities and the few differences. We then compare in extensive detail the underlying pathophysiology of these two conditions, focusing on abnormalities of the central and autonomic nervous system, lungs, heart, vasculature, immune system, gut microbiome, energy metabolism and redox balance. This comparison highlights how strong the evidence is for each abnormality, in each illness, and helps to set priorities for future investigation. The review provides a current road map to the extensive literature on the underlying biology of both illnesses.
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spelling pubmed-102785462023-06-20 ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature Komaroff, Anthony L. Lipkin, W. Ian Front Med (Lausanne) Medicine Some patients remain unwell for months after “recovering” from acute COVID-19. They develop persistent fatigue, cognitive problems, headaches, disrupted sleep, myalgias and arthralgias, post-exertional malaise, orthostatic intolerance and other symptoms that greatly interfere with their ability to function and that can leave some people housebound and disabled. The illness (Long COVID) is similar to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) as well as to persisting illnesses that can follow a wide variety of other infectious agents and following major traumatic injury. Together, these illnesses are projected to cost the U.S. trillions of dollars. In this review, we first compare the symptoms of ME/CFS and Long COVID, noting the considerable similarities and the few differences. We then compare in extensive detail the underlying pathophysiology of these two conditions, focusing on abnormalities of the central and autonomic nervous system, lungs, heart, vasculature, immune system, gut microbiome, energy metabolism and redox balance. This comparison highlights how strong the evidence is for each abnormality, in each illness, and helps to set priorities for future investigation. The review provides a current road map to the extensive literature on the underlying biology of both illnesses. Frontiers Media S.A. 2023-06-02 /pmc/articles/PMC10278546/ /pubmed/37342500 http://dx.doi.org/10.3389/fmed.2023.1187163 Text en Copyright © 2023 Komaroff and Lipkin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Komaroff, Anthony L.
Lipkin, W. Ian
ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature
title ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature
title_full ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature
title_fullStr ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature
title_full_unstemmed ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature
title_short ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature
title_sort me/cfs and long covid share similar symptoms and biological abnormalities: road map to the literature
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278546/
https://www.ncbi.nlm.nih.gov/pubmed/37342500
http://dx.doi.org/10.3389/fmed.2023.1187163
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