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Decomposing the Response Time in Amblyopia: A Drift Diffusion Model Analysis

PURPOSE: Amblyopes are known to have delayed response times (RT) in various visual tasks. We aim to investigate whether any factor other than the sensory deficit contributes to the delayed RT in amblyopia. METHOD: Fifteen amblyopic (26.0 ± 4.50 years) and 15 normal (25.6 ± 2.90 years) participants t...

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Autores principales: Ruan, Xiaowei, Lin, Liang, Ying, Xiaoxiao, Zhang, Hanyi, Yuan, Junli, Li, Cheng, Yang, Yan, Zhu, Jinli, Chen, Ruyin, Hou, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278554/
https://www.ncbi.nlm.nih.gov/pubmed/37318443
http://dx.doi.org/10.1167/iovs.64.7.25
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author Ruan, Xiaowei
Lin, Liang
Ying, Xiaoxiao
Zhang, Hanyi
Yuan, Junli
Li, Cheng
Yang, Yan
Zhu, Jinli
Chen, Ruyin
Hou, Fang
author_facet Ruan, Xiaowei
Lin, Liang
Ying, Xiaoxiao
Zhang, Hanyi
Yuan, Junli
Li, Cheng
Yang, Yan
Zhu, Jinli
Chen, Ruyin
Hou, Fang
author_sort Ruan, Xiaowei
collection PubMed
description PURPOSE: Amblyopes are known to have delayed response times (RT) in various visual tasks. We aim to investigate whether any factor other than the sensory deficit contributes to the delayed RT in amblyopia. METHOD: Fifteen amblyopic (26.0 ± 4.50 years) and 15 normal (25.6 ± 2.90 years) participants took part in this study. The responses and RTs in an orientation identification task were collected for each participant with stimulus contrast adjusted to the multiples of individual's threshold. A drift diffusion model was used to fit to the response and RT data and to estimate the RT components. RESULT: There was a significant difference in the RT between the amblyopic and normal groups (F(1, 28) = 6.75, P = 0.015) but no difference in the accuracy (F(1, 28) = 0.028, P = 0.868). The drift rate function in the amblyopic eye had a larger threshold (P = 0.001) and shallower slope (P = 0.006) than that of the fellow eye. The amblyopic group has a longer non-decision time than the normal group (F(1, 28) = 8.02, P = 0.008). The drift rate threshold correlated with the contrast sensitivity (P = 1.71 × 10(−18)) but the non-decision time did not (P = 0.393). CONCLUSIONS: Both sensory and post-sensory factors contributed to the delayed RT in amblyopia. The effect of the sensory loss in V1 on RT can be compensated by increasing stimulus contrast, and the post-sensory delay provides evidence for higher-level deficits in amblyopia.
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spelling pubmed-102785542023-06-20 Decomposing the Response Time in Amblyopia: A Drift Diffusion Model Analysis Ruan, Xiaowei Lin, Liang Ying, Xiaoxiao Zhang, Hanyi Yuan, Junli Li, Cheng Yang, Yan Zhu, Jinli Chen, Ruyin Hou, Fang Invest Ophthalmol Vis Sci Visual Psychophysics and Physiological Optics PURPOSE: Amblyopes are known to have delayed response times (RT) in various visual tasks. We aim to investigate whether any factor other than the sensory deficit contributes to the delayed RT in amblyopia. METHOD: Fifteen amblyopic (26.0 ± 4.50 years) and 15 normal (25.6 ± 2.90 years) participants took part in this study. The responses and RTs in an orientation identification task were collected for each participant with stimulus contrast adjusted to the multiples of individual's threshold. A drift diffusion model was used to fit to the response and RT data and to estimate the RT components. RESULT: There was a significant difference in the RT between the amblyopic and normal groups (F(1, 28) = 6.75, P = 0.015) but no difference in the accuracy (F(1, 28) = 0.028, P = 0.868). The drift rate function in the amblyopic eye had a larger threshold (P = 0.001) and shallower slope (P = 0.006) than that of the fellow eye. The amblyopic group has a longer non-decision time than the normal group (F(1, 28) = 8.02, P = 0.008). The drift rate threshold correlated with the contrast sensitivity (P = 1.71 × 10(−18)) but the non-decision time did not (P = 0.393). CONCLUSIONS: Both sensory and post-sensory factors contributed to the delayed RT in amblyopia. The effect of the sensory loss in V1 on RT can be compensated by increasing stimulus contrast, and the post-sensory delay provides evidence for higher-level deficits in amblyopia. The Association for Research in Vision and Ophthalmology 2023-06-15 /pmc/articles/PMC10278554/ /pubmed/37318443 http://dx.doi.org/10.1167/iovs.64.7.25 Text en Copyright 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Visual Psychophysics and Physiological Optics
Ruan, Xiaowei
Lin, Liang
Ying, Xiaoxiao
Zhang, Hanyi
Yuan, Junli
Li, Cheng
Yang, Yan
Zhu, Jinli
Chen, Ruyin
Hou, Fang
Decomposing the Response Time in Amblyopia: A Drift Diffusion Model Analysis
title Decomposing the Response Time in Amblyopia: A Drift Diffusion Model Analysis
title_full Decomposing the Response Time in Amblyopia: A Drift Diffusion Model Analysis
title_fullStr Decomposing the Response Time in Amblyopia: A Drift Diffusion Model Analysis
title_full_unstemmed Decomposing the Response Time in Amblyopia: A Drift Diffusion Model Analysis
title_short Decomposing the Response Time in Amblyopia: A Drift Diffusion Model Analysis
title_sort decomposing the response time in amblyopia: a drift diffusion model analysis
topic Visual Psychophysics and Physiological Optics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278554/
https://www.ncbi.nlm.nih.gov/pubmed/37318443
http://dx.doi.org/10.1167/iovs.64.7.25
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