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Characteristics of Henle’s fiber layer in healthy and glaucoma eyes assessed by polarization-sensitive optical coherence tomography
Using conventional optical coherence tomography (OCT), it is difficult to image Henle fibers (HF) due to their low backscattering potential. However, fibrous structures exhibit form birefringence, which can be exploited to visualize the presence of HF by polarization-sensitive (PS) OCT. We found a s...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Optica Publishing Group
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278601/ https://www.ncbi.nlm.nih.gov/pubmed/37342719 http://dx.doi.org/10.1364/BOE.485327 |
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author | Motschi, Alice R. Schwarzhans, Florian Desissaire, Sylvia Steiner, Stefan Bogunović, Hrvoje Roberts, Philipp K. Vass, Clemens Hitzenberger, Christoph K. Pircher, Michael |
author_facet | Motschi, Alice R. Schwarzhans, Florian Desissaire, Sylvia Steiner, Stefan Bogunović, Hrvoje Roberts, Philipp K. Vass, Clemens Hitzenberger, Christoph K. Pircher, Michael |
author_sort | Motschi, Alice R. |
collection | PubMed |
description | Using conventional optical coherence tomography (OCT), it is difficult to image Henle fibers (HF) due to their low backscattering potential. However, fibrous structures exhibit form birefringence, which can be exploited to visualize the presence of HF by polarization-sensitive (PS) OCT. We found a slight asymmetry in the retardation pattern of HF in the fovea region that can be associated with the asymmetric decrease of cone density with eccentricity from the fovea. We introduce a new measure based on a PS-OCT assessment of optic axis orientation to estimate the presence of HF at various eccentricities from the fovea in a large cohort of 150 healthy subjects. By comparing a healthy age-matched sub-group (N = 87) to a cohort of 64 early-stage glaucoma patients, we found no significant difference in HF extension but a slightly decreased retardation at about 2° to 7.5° eccentricity from the fovea in the glaucoma patients. This potentially indicates that glaucoma affects this neuronal tissue at an early state. |
format | Online Article Text |
id | pubmed-10278601 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Optica Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-102786012023-06-20 Characteristics of Henle’s fiber layer in healthy and glaucoma eyes assessed by polarization-sensitive optical coherence tomography Motschi, Alice R. Schwarzhans, Florian Desissaire, Sylvia Steiner, Stefan Bogunović, Hrvoje Roberts, Philipp K. Vass, Clemens Hitzenberger, Christoph K. Pircher, Michael Biomed Opt Express Article Using conventional optical coherence tomography (OCT), it is difficult to image Henle fibers (HF) due to their low backscattering potential. However, fibrous structures exhibit form birefringence, which can be exploited to visualize the presence of HF by polarization-sensitive (PS) OCT. We found a slight asymmetry in the retardation pattern of HF in the fovea region that can be associated with the asymmetric decrease of cone density with eccentricity from the fovea. We introduce a new measure based on a PS-OCT assessment of optic axis orientation to estimate the presence of HF at various eccentricities from the fovea in a large cohort of 150 healthy subjects. By comparing a healthy age-matched sub-group (N = 87) to a cohort of 64 early-stage glaucoma patients, we found no significant difference in HF extension but a slightly decreased retardation at about 2° to 7.5° eccentricity from the fovea in the glaucoma patients. This potentially indicates that glaucoma affects this neuronal tissue at an early state. Optica Publishing Group 2023-05-16 /pmc/articles/PMC10278601/ /pubmed/37342719 http://dx.doi.org/10.1364/BOE.485327 Text en Published by Optica Publishing Group under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI. https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Motschi, Alice R. Schwarzhans, Florian Desissaire, Sylvia Steiner, Stefan Bogunović, Hrvoje Roberts, Philipp K. Vass, Clemens Hitzenberger, Christoph K. Pircher, Michael Characteristics of Henle’s fiber layer in healthy and glaucoma eyes assessed by polarization-sensitive optical coherence tomography |
title | Characteristics of Henle’s fiber layer in healthy and glaucoma eyes assessed by polarization-sensitive optical coherence tomography |
title_full | Characteristics of Henle’s fiber layer in healthy and glaucoma eyes assessed by polarization-sensitive optical coherence tomography |
title_fullStr | Characteristics of Henle’s fiber layer in healthy and glaucoma eyes assessed by polarization-sensitive optical coherence tomography |
title_full_unstemmed | Characteristics of Henle’s fiber layer in healthy and glaucoma eyes assessed by polarization-sensitive optical coherence tomography |
title_short | Characteristics of Henle’s fiber layer in healthy and glaucoma eyes assessed by polarization-sensitive optical coherence tomography |
title_sort | characteristics of henle’s fiber layer in healthy and glaucoma eyes assessed by polarization-sensitive optical coherence tomography |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278601/ https://www.ncbi.nlm.nih.gov/pubmed/37342719 http://dx.doi.org/10.1364/BOE.485327 |
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