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Characteristics of Henle’s fiber layer in healthy and glaucoma eyes assessed by polarization-sensitive optical coherence tomography

Using conventional optical coherence tomography (OCT), it is difficult to image Henle fibers (HF) due to their low backscattering potential. However, fibrous structures exhibit form birefringence, which can be exploited to visualize the presence of HF by polarization-sensitive (PS) OCT. We found a s...

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Autores principales: Motschi, Alice R., Schwarzhans, Florian, Desissaire, Sylvia, Steiner, Stefan, Bogunović, Hrvoje, Roberts, Philipp K., Vass, Clemens, Hitzenberger, Christoph K., Pircher, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optica Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278601/
https://www.ncbi.nlm.nih.gov/pubmed/37342719
http://dx.doi.org/10.1364/BOE.485327
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author Motschi, Alice R.
Schwarzhans, Florian
Desissaire, Sylvia
Steiner, Stefan
Bogunović, Hrvoje
Roberts, Philipp K.
Vass, Clemens
Hitzenberger, Christoph K.
Pircher, Michael
author_facet Motschi, Alice R.
Schwarzhans, Florian
Desissaire, Sylvia
Steiner, Stefan
Bogunović, Hrvoje
Roberts, Philipp K.
Vass, Clemens
Hitzenberger, Christoph K.
Pircher, Michael
author_sort Motschi, Alice R.
collection PubMed
description Using conventional optical coherence tomography (OCT), it is difficult to image Henle fibers (HF) due to their low backscattering potential. However, fibrous structures exhibit form birefringence, which can be exploited to visualize the presence of HF by polarization-sensitive (PS) OCT. We found a slight asymmetry in the retardation pattern of HF in the fovea region that can be associated with the asymmetric decrease of cone density with eccentricity from the fovea. We introduce a new measure based on a PS-OCT assessment of optic axis orientation to estimate the presence of HF at various eccentricities from the fovea in a large cohort of 150 healthy subjects. By comparing a healthy age-matched sub-group (N = 87) to a cohort of 64 early-stage glaucoma patients, we found no significant difference in HF extension but a slightly decreased retardation at about 2° to 7.5° eccentricity from the fovea in the glaucoma patients. This potentially indicates that glaucoma affects this neuronal tissue at an early state.
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spelling pubmed-102786012023-06-20 Characteristics of Henle’s fiber layer in healthy and glaucoma eyes assessed by polarization-sensitive optical coherence tomography Motschi, Alice R. Schwarzhans, Florian Desissaire, Sylvia Steiner, Stefan Bogunović, Hrvoje Roberts, Philipp K. Vass, Clemens Hitzenberger, Christoph K. Pircher, Michael Biomed Opt Express Article Using conventional optical coherence tomography (OCT), it is difficult to image Henle fibers (HF) due to their low backscattering potential. However, fibrous structures exhibit form birefringence, which can be exploited to visualize the presence of HF by polarization-sensitive (PS) OCT. We found a slight asymmetry in the retardation pattern of HF in the fovea region that can be associated with the asymmetric decrease of cone density with eccentricity from the fovea. We introduce a new measure based on a PS-OCT assessment of optic axis orientation to estimate the presence of HF at various eccentricities from the fovea in a large cohort of 150 healthy subjects. By comparing a healthy age-matched sub-group (N = 87) to a cohort of 64 early-stage glaucoma patients, we found no significant difference in HF extension but a slightly decreased retardation at about 2° to 7.5° eccentricity from the fovea in the glaucoma patients. This potentially indicates that glaucoma affects this neuronal tissue at an early state. Optica Publishing Group 2023-05-16 /pmc/articles/PMC10278601/ /pubmed/37342719 http://dx.doi.org/10.1364/BOE.485327 Text en Published by Optica Publishing Group under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI. https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Motschi, Alice R.
Schwarzhans, Florian
Desissaire, Sylvia
Steiner, Stefan
Bogunović, Hrvoje
Roberts, Philipp K.
Vass, Clemens
Hitzenberger, Christoph K.
Pircher, Michael
Characteristics of Henle’s fiber layer in healthy and glaucoma eyes assessed by polarization-sensitive optical coherence tomography
title Characteristics of Henle’s fiber layer in healthy and glaucoma eyes assessed by polarization-sensitive optical coherence tomography
title_full Characteristics of Henle’s fiber layer in healthy and glaucoma eyes assessed by polarization-sensitive optical coherence tomography
title_fullStr Characteristics of Henle’s fiber layer in healthy and glaucoma eyes assessed by polarization-sensitive optical coherence tomography
title_full_unstemmed Characteristics of Henle’s fiber layer in healthy and glaucoma eyes assessed by polarization-sensitive optical coherence tomography
title_short Characteristics of Henle’s fiber layer in healthy and glaucoma eyes assessed by polarization-sensitive optical coherence tomography
title_sort characteristics of henle’s fiber layer in healthy and glaucoma eyes assessed by polarization-sensitive optical coherence tomography
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278601/
https://www.ncbi.nlm.nih.gov/pubmed/37342719
http://dx.doi.org/10.1364/BOE.485327
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