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Ferroptosis in acute leukemia
Ferroptosis is an iron-dependent cell death pathway that is different from apoptosis, pyroptosis, and necrosis. The main characteristics of ferroptosis are the Fenton reaction mediated by intracellular free divalent iron ions, lipid peroxidation of cell membrane lipids, and inhibition of the anti-li...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278762/ https://www.ncbi.nlm.nih.gov/pubmed/37010259 http://dx.doi.org/10.1097/CM9.0000000000002642 |
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author | Lyu, Tianxin Li, Xudong Song, Yongping |
author_facet | Lyu, Tianxin Li, Xudong Song, Yongping |
author_sort | Lyu, Tianxin |
collection | PubMed |
description | Ferroptosis is an iron-dependent cell death pathway that is different from apoptosis, pyroptosis, and necrosis. The main characteristics of ferroptosis are the Fenton reaction mediated by intracellular free divalent iron ions, lipid peroxidation of cell membrane lipids, and inhibition of the anti-lipid peroxidation activity of intracellular glutathione peroxidase 4 (GPX4). Recent studies have shown that ferroptosis can be involved in the pathological processes of many disorders, such as ischemia–reperfusion injury, nervous system diseases, and blood diseases. However, the specific mechanisms by which ferroptosis participates in the occurrence and development of acute leukemia still need to be more fully and deeply studied. This article reviews the characteristics of ferroptosis and the regulatory mechanisms promoting or inhibiting ferroptosis. More importantly, it further discusses the role of ferroptosis in acute leukemia and predicts a change in treatment strategy brought about by increased knowledge of the role of ferroptosis in acute leukemia. |
format | Online Article Text |
id | pubmed-10278762 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-102787622023-06-20 Ferroptosis in acute leukemia Lyu, Tianxin Li, Xudong Song, Yongping Chin Med J (Engl) Review Article Ferroptosis is an iron-dependent cell death pathway that is different from apoptosis, pyroptosis, and necrosis. The main characteristics of ferroptosis are the Fenton reaction mediated by intracellular free divalent iron ions, lipid peroxidation of cell membrane lipids, and inhibition of the anti-lipid peroxidation activity of intracellular glutathione peroxidase 4 (GPX4). Recent studies have shown that ferroptosis can be involved in the pathological processes of many disorders, such as ischemia–reperfusion injury, nervous system diseases, and blood diseases. However, the specific mechanisms by which ferroptosis participates in the occurrence and development of acute leukemia still need to be more fully and deeply studied. This article reviews the characteristics of ferroptosis and the regulatory mechanisms promoting or inhibiting ferroptosis. More importantly, it further discusses the role of ferroptosis in acute leukemia and predicts a change in treatment strategy brought about by increased knowledge of the role of ferroptosis in acute leukemia. Lippincott Williams & Wilkins 2023-04-03 2023-04-20 /pmc/articles/PMC10278762/ /pubmed/37010259 http://dx.doi.org/10.1097/CM9.0000000000002642 Text en Copyright © 2023 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Review Article Lyu, Tianxin Li, Xudong Song, Yongping Ferroptosis in acute leukemia |
title | Ferroptosis in acute leukemia |
title_full | Ferroptosis in acute leukemia |
title_fullStr | Ferroptosis in acute leukemia |
title_full_unstemmed | Ferroptosis in acute leukemia |
title_short | Ferroptosis in acute leukemia |
title_sort | ferroptosis in acute leukemia |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278762/ https://www.ncbi.nlm.nih.gov/pubmed/37010259 http://dx.doi.org/10.1097/CM9.0000000000002642 |
work_keys_str_mv | AT lyutianxin ferroptosisinacuteleukemia AT lixudong ferroptosisinacuteleukemia AT songyongping ferroptosisinacuteleukemia |