Tissue Inhibitor Metalloproteinase-2 and Insulin-Like Growth Factor Binding Protein-7 Kinetics Following Exposure to High-Dose Methotrexate

Urinary TIMP2×IGFBP7 (uTIMP2×IGFBP7) concentrations experienced a rapid and sustained decline after high-dose methotrexate (MTX) exposure. uTIMP2×IGFBP7 kinetics and concentrations after high-dose MTX exposure demonstrated no utility in predicting AKI.

Detalles Bibliográficos
Autores principales: Barreto, Jason N., Barreto, Erin F., Mara, Kristin C., Rule, Andrew D., Lieske, John C., Giesen, Callen D., Thompson, Carrie A., Leung, Nelson, Witzig, Thomas E., Kashani, Kianoush B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Nephrology 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278852/
https://www.ncbi.nlm.nih.gov/pubmed/36888987
http://dx.doi.org/10.34067/KID.0000000000000099
Descripción
Sumario:Urinary TIMP2×IGFBP7 (uTIMP2×IGFBP7) concentrations experienced a rapid and sustained decline after high-dose methotrexate (MTX) exposure. uTIMP2×IGFBP7 kinetics and concentrations after high-dose MTX exposure demonstrated no utility in predicting AKI.

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