Asymmetric Catalytic Access to Piperazin-2-ones and Morpholin-2-ones in a One-Pot Approach: Rapid Synthesis of an Intermediate to Aprepitant

[Image: see text] A one-pot Knoevenagel reaction/asymmetric epoxidation/domino ring-opening cyclization (DROC) has been developed from commercial aldehydes, (phenylsulfonyl)acetonitrile, cumyl hydroperoxide, 1,2-ethylendiamines, and 1,2-ethanol amines to provide 3-aryl/alkyl piperazin-2-ones and mor...

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Detalles Bibliográficos
Autores principales: Meninno, Sara, Lattanzi, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278953/
https://www.ncbi.nlm.nih.gov/pubmed/36808952
http://dx.doi.org/10.1021/acs.joc.2c02491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278953/
https://www.ncbi.nlm.nih.gov/pubmed/36808952
http://dx.doi.org/10.1021/acs.joc.2c02491

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