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Analyzing the effect of the COVID-19 vaccine on Parkinson’s disease symptoms
BACKGROUND: Parkinson’s Disease (PD) is one of the most common neurodegenerative diseases. PD has recently received more attention by researchers in the midst of the COVID-19 pandemic. OBJECTIVE: Yet to be researched is the effect of the COVID-19 vaccines on PD patients. Several PD patients are stil...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278957/ https://www.ncbi.nlm.nih.gov/pubmed/37342344 http://dx.doi.org/10.3389/fimmu.2023.1158364 |
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author | Sabat, Revati Dayton, Orrin L. Agarwal, Amit Vedam-Mai, Vinata |
author_facet | Sabat, Revati Dayton, Orrin L. Agarwal, Amit Vedam-Mai, Vinata |
author_sort | Sabat, Revati |
collection | PubMed |
description | BACKGROUND: Parkinson’s Disease (PD) is one of the most common neurodegenerative diseases. PD has recently received more attention by researchers in the midst of the COVID-19 pandemic. OBJECTIVE: Yet to be researched is the effect of the COVID-19 vaccines on PD patients. Several PD patients are still hesitant to the vaccine due to this unaddressed fear. The purpose of this study is to address this gap. METHODS: Surveys were administered to PD patients 50 years and older at UF Fixel Institute who received at least one dose of the COVID-19 vaccine. Survey questions included patients’ severity of PD symptoms before and after the vaccine and extent of worsening PD symptoms post-vaccination. After three weeks of collecting responses, the data was analyzed. RESULTS: 34 respondents were eligible for data consideration because they fell within the age range being studied. A total of 14 respondents out of 34 (41%, p=0. 0001) reported that their PD symptoms worsened after the COVID-19 vaccine to some extent. CONCLUSION: There was strong evidence of worsening of PD symptoms post COVID-19 vaccination, however it was mostly mild and limited to a couple of days. The worsening had statistically significant moderate positive correlation with vaccine hesitancy and post-vaccine general side effects. A possible causative mechanism of PD symptom worsening using existing scientific knowledge would be stress and anxiety associated with vaccine hesitancy and the extent of post-vaccine general side effects (fever, chills, pain), likely via simulating a mild systemic infection/inflammation the latter already established causes of PD symptom worsening. |
format | Online Article Text |
id | pubmed-10278957 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102789572023-06-20 Analyzing the effect of the COVID-19 vaccine on Parkinson’s disease symptoms Sabat, Revati Dayton, Orrin L. Agarwal, Amit Vedam-Mai, Vinata Front Immunol Immunology BACKGROUND: Parkinson’s Disease (PD) is one of the most common neurodegenerative diseases. PD has recently received more attention by researchers in the midst of the COVID-19 pandemic. OBJECTIVE: Yet to be researched is the effect of the COVID-19 vaccines on PD patients. Several PD patients are still hesitant to the vaccine due to this unaddressed fear. The purpose of this study is to address this gap. METHODS: Surveys were administered to PD patients 50 years and older at UF Fixel Institute who received at least one dose of the COVID-19 vaccine. Survey questions included patients’ severity of PD symptoms before and after the vaccine and extent of worsening PD symptoms post-vaccination. After three weeks of collecting responses, the data was analyzed. RESULTS: 34 respondents were eligible for data consideration because they fell within the age range being studied. A total of 14 respondents out of 34 (41%, p=0. 0001) reported that their PD symptoms worsened after the COVID-19 vaccine to some extent. CONCLUSION: There was strong evidence of worsening of PD symptoms post COVID-19 vaccination, however it was mostly mild and limited to a couple of days. The worsening had statistically significant moderate positive correlation with vaccine hesitancy and post-vaccine general side effects. A possible causative mechanism of PD symptom worsening using existing scientific knowledge would be stress and anxiety associated with vaccine hesitancy and the extent of post-vaccine general side effects (fever, chills, pain), likely via simulating a mild systemic infection/inflammation the latter already established causes of PD symptom worsening. Frontiers Media S.A. 2023-06-05 /pmc/articles/PMC10278957/ /pubmed/37342344 http://dx.doi.org/10.3389/fimmu.2023.1158364 Text en Copyright © 2023 Sabat, Dayton, Agarwal and Vedam-Mai https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Sabat, Revati Dayton, Orrin L. Agarwal, Amit Vedam-Mai, Vinata Analyzing the effect of the COVID-19 vaccine on Parkinson’s disease symptoms |
title | Analyzing the effect of the COVID-19 vaccine on Parkinson’s disease symptoms |
title_full | Analyzing the effect of the COVID-19 vaccine on Parkinson’s disease symptoms |
title_fullStr | Analyzing the effect of the COVID-19 vaccine on Parkinson’s disease symptoms |
title_full_unstemmed | Analyzing the effect of the COVID-19 vaccine on Parkinson’s disease symptoms |
title_short | Analyzing the effect of the COVID-19 vaccine on Parkinson’s disease symptoms |
title_sort | analyzing the effect of the covid-19 vaccine on parkinson’s disease symptoms |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278957/ https://www.ncbi.nlm.nih.gov/pubmed/37342344 http://dx.doi.org/10.3389/fimmu.2023.1158364 |
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