Deciphering the Shared and Specific Drug Resistance Mechanisms of Anaplastic Lymphoma Kinase via Binding Free Energy Computation

Anaplastic lymphoma kinase (ALK), a tyrosine receptor kinase, has been proven to be associated with the occurrence of numerous malignancies. Although there have been already at least 3 generations of ALK inhibitors approved by FDA or in clinical trials, the occurrence of various mutations seriously...

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Detalles Bibliográficos
Autores principales: Yu, Yang, Wang, Zhe, Wang, Lingling, Wang, Qinghua, Tang, Rongfan, Xiang, Sutong, Deng, Qirui, Hou, Tingjun, Sun, Huiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAAS 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278961/
https://www.ncbi.nlm.nih.gov/pubmed/37342628
http://dx.doi.org/10.34133/research.0170

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