Cargando…
Impact of sperm DNA fragmentation on the clinical outcome of assisted reproduction techniques: a systematic review of the last five years
OBJECTIVE: To elucidate through a systematic literature review the impact sperm DNA fragmentation has on embryos from assisted reproduction techniques. DATA SOURCE: Studies from the “PubMed”, “Embase”, and “BVS” databases were analyzed. STUDIES SELECTION: The articles selected in the review included...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Brazilian Society of Assisted Reproduction
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279435/ https://www.ncbi.nlm.nih.gov/pubmed/36749810 http://dx.doi.org/10.5935/1518-0557.20220057 |
_version_ | 1785060591785738240 |
---|---|
author | Lourenço, Mayara Lobato de Moura, Gabriel Acácio Rocha, Yasmim Mendes Rodrigues, João Pedro Viana Monteiro, Paula Bruno |
author_facet | Lourenço, Mayara Lobato de Moura, Gabriel Acácio Rocha, Yasmim Mendes Rodrigues, João Pedro Viana Monteiro, Paula Bruno |
author_sort | Lourenço, Mayara Lobato |
collection | PubMed |
description | OBJECTIVE: To elucidate through a systematic literature review the impact sperm DNA fragmentation has on embryos from assisted reproduction techniques. DATA SOURCE: Studies from the “PubMed”, “Embase”, and “BVS” databases were analyzed. STUDIES SELECTION: The articles selected in the review included: cohort and case-control studies that addressed the proposed theme, published between January 1, 2017, and January 31, 2022, in English, Portuguese, and Spanish. As inclusion criteria: cohort and case-control articles. As exclusion criteria: articles outside the scope of the research, review articles, case reports, articles using animal models, abstracts, letters to the editor, and articles found duplicates in the databases. DATA COLLECTION: Number of couples or cycles; age (men/women); collection type; DNA damage (%); assisted reproduction activity and techniques. DATA SYNTHESIS: In in vitro fertilization, a reduction in fertilization rate, blastocyst rate, and embryo quality was observed. In addition to implantation and increased abortion rates in patients with high sperm DNA fragmentation. High rates of sperm DNA fragmentation in intracytoplasmic sperm injection led to reduced blastocyst production rate, embryo quality, implantation, and live birth rate, and in intrauterine insemination, a reduction in pregnancy rate. CONCLUSION: Sperm DNA fragmentation was a potential limiting factor for assisted reproduction techniques. |
format | Online Article Text |
id | pubmed-10279435 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Brazilian Society of Assisted Reproduction |
record_format | MEDLINE/PubMed |
spelling | pubmed-102794352023-06-20 Impact of sperm DNA fragmentation on the clinical outcome of assisted reproduction techniques: a systematic review of the last five years Lourenço, Mayara Lobato de Moura, Gabriel Acácio Rocha, Yasmim Mendes Rodrigues, João Pedro Viana Monteiro, Paula Bruno JBRA Assist Reprod Review OBJECTIVE: To elucidate through a systematic literature review the impact sperm DNA fragmentation has on embryos from assisted reproduction techniques. DATA SOURCE: Studies from the “PubMed”, “Embase”, and “BVS” databases were analyzed. STUDIES SELECTION: The articles selected in the review included: cohort and case-control studies that addressed the proposed theme, published between January 1, 2017, and January 31, 2022, in English, Portuguese, and Spanish. As inclusion criteria: cohort and case-control articles. As exclusion criteria: articles outside the scope of the research, review articles, case reports, articles using animal models, abstracts, letters to the editor, and articles found duplicates in the databases. DATA COLLECTION: Number of couples or cycles; age (men/women); collection type; DNA damage (%); assisted reproduction activity and techniques. DATA SYNTHESIS: In in vitro fertilization, a reduction in fertilization rate, blastocyst rate, and embryo quality was observed. In addition to implantation and increased abortion rates in patients with high sperm DNA fragmentation. High rates of sperm DNA fragmentation in intracytoplasmic sperm injection led to reduced blastocyst production rate, embryo quality, implantation, and live birth rate, and in intrauterine insemination, a reduction in pregnancy rate. CONCLUSION: Sperm DNA fragmentation was a potential limiting factor for assisted reproduction techniques. Brazilian Society of Assisted Reproduction 2023 /pmc/articles/PMC10279435/ /pubmed/36749810 http://dx.doi.org/10.5935/1518-0557.20220057 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Lourenço, Mayara Lobato de Moura, Gabriel Acácio Rocha, Yasmim Mendes Rodrigues, João Pedro Viana Monteiro, Paula Bruno Impact of sperm DNA fragmentation on the clinical outcome of assisted reproduction techniques: a systematic review of the last five years |
title | Impact of sperm DNA fragmentation on the clinical outcome of assisted
reproduction techniques: a systematic review of the last five
years |
title_full | Impact of sperm DNA fragmentation on the clinical outcome of assisted
reproduction techniques: a systematic review of the last five
years |
title_fullStr | Impact of sperm DNA fragmentation on the clinical outcome of assisted
reproduction techniques: a systematic review of the last five
years |
title_full_unstemmed | Impact of sperm DNA fragmentation on the clinical outcome of assisted
reproduction techniques: a systematic review of the last five
years |
title_short | Impact of sperm DNA fragmentation on the clinical outcome of assisted
reproduction techniques: a systematic review of the last five
years |
title_sort | impact of sperm dna fragmentation on the clinical outcome of assisted
reproduction techniques: a systematic review of the last five
years |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279435/ https://www.ncbi.nlm.nih.gov/pubmed/36749810 http://dx.doi.org/10.5935/1518-0557.20220057 |
work_keys_str_mv | AT lourencomayaralobato impactofspermdnafragmentationontheclinicaloutcomeofassistedreproductiontechniquesasystematicreviewofthelastfiveyears AT demouragabrielacacio impactofspermdnafragmentationontheclinicaloutcomeofassistedreproductiontechniquesasystematicreviewofthelastfiveyears AT rochayasmimmendes impactofspermdnafragmentationontheclinicaloutcomeofassistedreproductiontechniquesasystematicreviewofthelastfiveyears AT rodriguesjoaopedroviana impactofspermdnafragmentationontheclinicaloutcomeofassistedreproductiontechniquesasystematicreviewofthelastfiveyears AT monteiropaulabruno impactofspermdnafragmentationontheclinicaloutcomeofassistedreproductiontechniquesasystematicreviewofthelastfiveyears |