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Impaired factor V–related anticoagulant mechanisms and deep vein thrombosis associated with A2086D and W1920R mutations

Factor V (FV) plays pivotal roles in both procoagulant and anticoagulant mechanisms. Genetic mutations, FV-W1920R (FV(Nara)) and FV-A2086D (FV(Besançon)), in the C1 and C2 domains of FV light chain, respectively, seem to be associated with deep vein thrombosis. However, the detailed mechanism(s) thr...

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Detalles Bibliográficos
Autores principales:	Shimonishi, Naruto, Ogiwara, Kenichi, Yoshida, Junko, Horie, Kyoji, Nakajima, Yuto, Furukawa, Shoko, Takeyama, Masahiro, Nogami, Keiji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society of Hematology 2023
Materias:	Thrombosis and Hemostasis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279549/ https://www.ncbi.nlm.nih.gov/pubmed/36780344 http://dx.doi.org/10.1182/bloodadvances.2022008918

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