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Immune compartments at the brain’s borders in health and neurovascular diseases

Recent evidence implicates cranial border immune compartments in the meninges, choroid plexus, circumventricular organs, and skull bone marrow in several neuroinflammatory and neoplastic diseases. Their pathogenic importance has also been described for cardiovascular diseases such as hypertension an...

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Detalles Bibliográficos
Autores principales: Goertz, Jennifer E., Garcia-Bonilla, Lidia, Iadecola, Costantino, Anrather, Josef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279585/
https://www.ncbi.nlm.nih.gov/pubmed/37138042
http://dx.doi.org/10.1007/s00281-023-00992-6
Descripción
Sumario:Recent evidence implicates cranial border immune compartments in the meninges, choroid plexus, circumventricular organs, and skull bone marrow in several neuroinflammatory and neoplastic diseases. Their pathogenic importance has also been described for cardiovascular diseases such as hypertension and stroke. In this review, we will examine the cellular composition of these cranial border immune niches, the potential pathways through which they might interact, and the evidence linking them to cardiovascular disease.