Cargando…

Anatomically guided self-adapting deep neural network for clinically significant prostate cancer detection on bi-parametric MRI: a multi-center study

OBJECTIVE: To evaluate the effectiveness of a self-adapting deep network, trained on large-scale bi-parametric MRI data, in detecting clinically significant prostate cancer (csPCa) in external multi-center data from men of diverse demographics; to investigate the advantages of transfer learning. MET...

Descripción completa

Detalles Bibliográficos
Autores principales: Karagoz, Ahmet, Alis, Deniz, Seker, Mustafa Ege, Zeybel, Gokberk, Yergin, Mert, Oksuz, Ilkay, Karaarslan, Ercan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279591/
https://www.ncbi.nlm.nih.gov/pubmed/37337101
http://dx.doi.org/10.1186/s13244-023-01439-0
_version_ 1785060623205269504
author Karagoz, Ahmet
Alis, Deniz
Seker, Mustafa Ege
Zeybel, Gokberk
Yergin, Mert
Oksuz, Ilkay
Karaarslan, Ercan
author_facet Karagoz, Ahmet
Alis, Deniz
Seker, Mustafa Ege
Zeybel, Gokberk
Yergin, Mert
Oksuz, Ilkay
Karaarslan, Ercan
author_sort Karagoz, Ahmet
collection PubMed
description OBJECTIVE: To evaluate the effectiveness of a self-adapting deep network, trained on large-scale bi-parametric MRI data, in detecting clinically significant prostate cancer (csPCa) in external multi-center data from men of diverse demographics; to investigate the advantages of transfer learning. METHODS: We used two samples: (i) Publicly available multi-center and multi-vendor Prostate Imaging: Cancer AI (PI-CAI) training data, consisting of 1500 bi-parametric MRI scans, along with its unseen validation and testing samples; (ii) In-house multi-center testing and transfer learning data, comprising 1036 and 200 bi-parametric MRI scans. We trained a self-adapting 3D nnU-Net model using probabilistic prostate masks on the PI-CAI data and evaluated its performance on the hidden validation and testing samples and the in-house data with and without transfer learning. We used the area under the receiver operating characteristic (AUROC) curve to evaluate patient-level performance in detecting csPCa. RESULTS: The PI-CAI training data had 425 scans with csPCa, while the in-house testing and fine-tuning data had 288 and 50 scans with csPCa, respectively. The nnU-Net model achieved an AUROC of 0.888 and 0.889 on the hidden validation and testing data. The model performed with an AUROC of 0.886 on the in-house testing data, with a slight decrease in performance to 0.870 using transfer learning. CONCLUSIONS: The state-of-the-art deep learning method using prostate masks trained on large-scale bi-parametric MRI data provides high performance in detecting csPCa in internal and external testing data with different characteristics, demonstrating the robustness and generalizability of deep learning within and across datasets. CLINICAL RELEVANCE STATEMENT: A self-adapting deep network, utilizing prostate masks and trained on large-scale bi-parametric MRI data, is effective in accurately detecting clinically significant prostate cancer across diverse datasets, highlighting the potential of deep learning methods for improving prostate cancer detection in clinical practice. GRAPHICAL ABSTRACT: [Image: see text]
format Online
Article
Text
id pubmed-10279591
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Springer Vienna
record_format MEDLINE/PubMed
spelling pubmed-102795912023-06-21 Anatomically guided self-adapting deep neural network for clinically significant prostate cancer detection on bi-parametric MRI: a multi-center study Karagoz, Ahmet Alis, Deniz Seker, Mustafa Ege Zeybel, Gokberk Yergin, Mert Oksuz, Ilkay Karaarslan, Ercan Insights Imaging Original Article OBJECTIVE: To evaluate the effectiveness of a self-adapting deep network, trained on large-scale bi-parametric MRI data, in detecting clinically significant prostate cancer (csPCa) in external multi-center data from men of diverse demographics; to investigate the advantages of transfer learning. METHODS: We used two samples: (i) Publicly available multi-center and multi-vendor Prostate Imaging: Cancer AI (PI-CAI) training data, consisting of 1500 bi-parametric MRI scans, along with its unseen validation and testing samples; (ii) In-house multi-center testing and transfer learning data, comprising 1036 and 200 bi-parametric MRI scans. We trained a self-adapting 3D nnU-Net model using probabilistic prostate masks on the PI-CAI data and evaluated its performance on the hidden validation and testing samples and the in-house data with and without transfer learning. We used the area under the receiver operating characteristic (AUROC) curve to evaluate patient-level performance in detecting csPCa. RESULTS: The PI-CAI training data had 425 scans with csPCa, while the in-house testing and fine-tuning data had 288 and 50 scans with csPCa, respectively. The nnU-Net model achieved an AUROC of 0.888 and 0.889 on the hidden validation and testing data. The model performed with an AUROC of 0.886 on the in-house testing data, with a slight decrease in performance to 0.870 using transfer learning. CONCLUSIONS: The state-of-the-art deep learning method using prostate masks trained on large-scale bi-parametric MRI data provides high performance in detecting csPCa in internal and external testing data with different characteristics, demonstrating the robustness and generalizability of deep learning within and across datasets. CLINICAL RELEVANCE STATEMENT: A self-adapting deep network, utilizing prostate masks and trained on large-scale bi-parametric MRI data, is effective in accurately detecting clinically significant prostate cancer across diverse datasets, highlighting the potential of deep learning methods for improving prostate cancer detection in clinical practice. GRAPHICAL ABSTRACT: [Image: see text] Springer Vienna 2023-06-19 /pmc/articles/PMC10279591/ /pubmed/37337101 http://dx.doi.org/10.1186/s13244-023-01439-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Karagoz, Ahmet
Alis, Deniz
Seker, Mustafa Ege
Zeybel, Gokberk
Yergin, Mert
Oksuz, Ilkay
Karaarslan, Ercan
Anatomically guided self-adapting deep neural network for clinically significant prostate cancer detection on bi-parametric MRI: a multi-center study
title Anatomically guided self-adapting deep neural network for clinically significant prostate cancer detection on bi-parametric MRI: a multi-center study
title_full Anatomically guided self-adapting deep neural network for clinically significant prostate cancer detection on bi-parametric MRI: a multi-center study
title_fullStr Anatomically guided self-adapting deep neural network for clinically significant prostate cancer detection on bi-parametric MRI: a multi-center study
title_full_unstemmed Anatomically guided self-adapting deep neural network for clinically significant prostate cancer detection on bi-parametric MRI: a multi-center study
title_short Anatomically guided self-adapting deep neural network for clinically significant prostate cancer detection on bi-parametric MRI: a multi-center study
title_sort anatomically guided self-adapting deep neural network for clinically significant prostate cancer detection on bi-parametric mri: a multi-center study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279591/
https://www.ncbi.nlm.nih.gov/pubmed/37337101
http://dx.doi.org/10.1186/s13244-023-01439-0
work_keys_str_mv AT karagozahmet anatomicallyguidedselfadaptingdeepneuralnetworkforclinicallysignificantprostatecancerdetectiononbiparametricmriamulticenterstudy
AT alisdeniz anatomicallyguidedselfadaptingdeepneuralnetworkforclinicallysignificantprostatecancerdetectiononbiparametricmriamulticenterstudy
AT sekermustafaege anatomicallyguidedselfadaptingdeepneuralnetworkforclinicallysignificantprostatecancerdetectiononbiparametricmriamulticenterstudy
AT zeybelgokberk anatomicallyguidedselfadaptingdeepneuralnetworkforclinicallysignificantprostatecancerdetectiononbiparametricmriamulticenterstudy
AT yerginmert anatomicallyguidedselfadaptingdeepneuralnetworkforclinicallysignificantprostatecancerdetectiononbiparametricmriamulticenterstudy
AT oksuzilkay anatomicallyguidedselfadaptingdeepneuralnetworkforclinicallysignificantprostatecancerdetectiononbiparametricmriamulticenterstudy
AT karaarslanercan anatomicallyguidedselfadaptingdeepneuralnetworkforclinicallysignificantprostatecancerdetectiononbiparametricmriamulticenterstudy