Repurposing of neprilysin inhibitor ‘sacubitrilat’ as an anti-cancer drug by modulating epigenetic and apoptotic regulators

Modifications in the epigenetic landscape have been considered a hallmark of cancer. Histone deacetylation is one of the crucial epigenetic modulations associated with the aggressive progression of various cancer subtypes. Herein, we have repurposed the neprilysin inhibitor sacubitrilat as a potent...

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Detalles Bibliográficos
Autores principales: Kumbhar, Navanath, Nimal, Snehal, Patil, Deeksha, Kaiser, V. Florian, Haupt, Joachim, Gacche, Rajesh N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279647/
https://www.ncbi.nlm.nih.gov/pubmed/37336927
http://dx.doi.org/10.1038/s41598-023-36872-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279647/
https://www.ncbi.nlm.nih.gov/pubmed/37336927
http://dx.doi.org/10.1038/s41598-023-36872-0

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