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Inflammatory cytokines and chemokines in obese adolescents with antibody against to adenovirus 36

Obesity in adolescents has reached epidemic proportions and is associated with the inflammatory response and viral infections. The aim of this study was to understand the profile of inflammatory cytokines and chemokines associated with the inflammatory response and metabolic syndrome (MetS) in obese...

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Autores principales: Sanches, Marcelo D’Alessandre, Goldberg, Tamara Beres Lederer, Rizzo, Anapaula da Conceição Bisi, da Silva, Valéria Nóbrega, Mosca, Luciana Nunes, Romagnoli, Graziela Gorete, Gorgulho, Carolina Mendonça, Araujo Junior, João Pessoa, de Lima, Gustavo Ramos, Betti, Isabella Rodrigues, Kurokawa, Cilmery Suemi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279706/
https://www.ncbi.nlm.nih.gov/pubmed/37336969
http://dx.doi.org/10.1038/s41598-023-33084-4
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author Sanches, Marcelo D’Alessandre
Goldberg, Tamara Beres Lederer
Rizzo, Anapaula da Conceição Bisi
da Silva, Valéria Nóbrega
Mosca, Luciana Nunes
Romagnoli, Graziela Gorete
Gorgulho, Carolina Mendonça
Araujo Junior, João Pessoa
de Lima, Gustavo Ramos
Betti, Isabella Rodrigues
Kurokawa, Cilmery Suemi
author_facet Sanches, Marcelo D’Alessandre
Goldberg, Tamara Beres Lederer
Rizzo, Anapaula da Conceição Bisi
da Silva, Valéria Nóbrega
Mosca, Luciana Nunes
Romagnoli, Graziela Gorete
Gorgulho, Carolina Mendonça
Araujo Junior, João Pessoa
de Lima, Gustavo Ramos
Betti, Isabella Rodrigues
Kurokawa, Cilmery Suemi
author_sort Sanches, Marcelo D’Alessandre
collection PubMed
description Obesity in adolescents has reached epidemic proportions and is associated with the inflammatory response and viral infections. The aim of this study was to understand the profile of inflammatory cytokines and chemokines associated with the inflammatory response and metabolic syndrome (MetS) in obese adolescents with positive serology for adenovirus 36 (ADV36). Thirty-six overweight, 36 obese, and 25 severe obesity adolescents aged 10 to 16 years were included in the study. The following variables were analyzed: sex, age, body mass index (BMI), blood pressure, total cholesterol and fractions, triglycerides, glucose, serum cytokine concentrations, and ADV36 antibodies. Cytokines and chemokines were quantified by cytometry and ADV36 serology was determined by enzyme-linked immunosorbent assay (ELISA). The results showed higher levels of the cytokines interleukin-1beta (IL-1β), IL-6, IL-10 and of the chemokine interferon-gamma-inducible protein 10 (IP-10) in severe obesity adolescents compared to the obese and overweight groups, as well as in the group with MetS compared to the group without this syndrome. The frequency of ADV36-positive individuals did not differ between groups. The findings revealed differences in BMI between the obese and severe obesity groups versus the overweight group in the presence of positivity for ADV36, suggesting an association with weight gain and possibly MetS installation.
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spelling pubmed-102797062023-06-21 Inflammatory cytokines and chemokines in obese adolescents with antibody against to adenovirus 36 Sanches, Marcelo D’Alessandre Goldberg, Tamara Beres Lederer Rizzo, Anapaula da Conceição Bisi da Silva, Valéria Nóbrega Mosca, Luciana Nunes Romagnoli, Graziela Gorete Gorgulho, Carolina Mendonça Araujo Junior, João Pessoa de Lima, Gustavo Ramos Betti, Isabella Rodrigues Kurokawa, Cilmery Suemi Sci Rep Article Obesity in adolescents has reached epidemic proportions and is associated with the inflammatory response and viral infections. The aim of this study was to understand the profile of inflammatory cytokines and chemokines associated with the inflammatory response and metabolic syndrome (MetS) in obese adolescents with positive serology for adenovirus 36 (ADV36). Thirty-six overweight, 36 obese, and 25 severe obesity adolescents aged 10 to 16 years were included in the study. The following variables were analyzed: sex, age, body mass index (BMI), blood pressure, total cholesterol and fractions, triglycerides, glucose, serum cytokine concentrations, and ADV36 antibodies. Cytokines and chemokines were quantified by cytometry and ADV36 serology was determined by enzyme-linked immunosorbent assay (ELISA). The results showed higher levels of the cytokines interleukin-1beta (IL-1β), IL-6, IL-10 and of the chemokine interferon-gamma-inducible protein 10 (IP-10) in severe obesity adolescents compared to the obese and overweight groups, as well as in the group with MetS compared to the group without this syndrome. The frequency of ADV36-positive individuals did not differ between groups. The findings revealed differences in BMI between the obese and severe obesity groups versus the overweight group in the presence of positivity for ADV36, suggesting an association with weight gain and possibly MetS installation. Nature Publishing Group UK 2023-06-19 /pmc/articles/PMC10279706/ /pubmed/37336969 http://dx.doi.org/10.1038/s41598-023-33084-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Sanches, Marcelo D’Alessandre
Goldberg, Tamara Beres Lederer
Rizzo, Anapaula da Conceição Bisi
da Silva, Valéria Nóbrega
Mosca, Luciana Nunes
Romagnoli, Graziela Gorete
Gorgulho, Carolina Mendonça
Araujo Junior, João Pessoa
de Lima, Gustavo Ramos
Betti, Isabella Rodrigues
Kurokawa, Cilmery Suemi
Inflammatory cytokines and chemokines in obese adolescents with antibody against to adenovirus 36
title Inflammatory cytokines and chemokines in obese adolescents with antibody against to adenovirus 36
title_full Inflammatory cytokines and chemokines in obese adolescents with antibody against to adenovirus 36
title_fullStr Inflammatory cytokines and chemokines in obese adolescents with antibody against to adenovirus 36
title_full_unstemmed Inflammatory cytokines and chemokines in obese adolescents with antibody against to adenovirus 36
title_short Inflammatory cytokines and chemokines in obese adolescents with antibody against to adenovirus 36
title_sort inflammatory cytokines and chemokines in obese adolescents with antibody against to adenovirus 36
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279706/
https://www.ncbi.nlm.nih.gov/pubmed/37336969
http://dx.doi.org/10.1038/s41598-023-33084-4
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