Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling

PEAK pseudokinases regulate cell migration, invasion and proliferation by recruiting key signaling proteins to the cytoskeleton. Despite lacking catalytic activity, alteration in their expression level is associated with several aggressive cancers. Here, we elucidate the molecular details of key PEA...

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Detalles Bibliográficos
Autores principales: Roy, Michael J., Surudoi, Minglyanna G., Kropp, Ashleigh, Hou, Jianmei, Dai, Weiwen, Hardy, Joshua M., Liang, Lung-Yu, Cotton, Thomas R., Lechtenberg, Bernhard C., Dite, Toby A., Ma, Xiuquan, Daly, Roger J., Patel, Onisha, Lucet, Isabelle S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279719/
https://www.ncbi.nlm.nih.gov/pubmed/37336884
http://dx.doi.org/10.1038/s41467-023-38869-9

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