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Conditions for the origin of homochirality in primordial catalytic reaction networks
We study the generation of homochirality in a general chemical model (based on the homogeneous, fully connected Smoluchowski aggregation-fragmentation model) that obeys thermodynamics and can be easily mapped onto known origin of life models (e.g. autocatalytic sets, hypercycles, etc.), with essenti...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279737/ https://www.ncbi.nlm.nih.gov/pubmed/37336897 http://dx.doi.org/10.1038/s41598-023-36852-4 |
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author | Gagnon, Jean-Sébastien Hochberg, David |
author_facet | Gagnon, Jean-Sébastien Hochberg, David |
author_sort | Gagnon, Jean-Sébastien |
collection | PubMed |
description | We study the generation of homochirality in a general chemical model (based on the homogeneous, fully connected Smoluchowski aggregation-fragmentation model) that obeys thermodynamics and can be easily mapped onto known origin of life models (e.g. autocatalytic sets, hypercycles, etc.), with essential aspects of origin of life modeling taken into consideration. Using a combination of theoretical modeling and numerical simulations, we look for minimal conditions for which our general chemical model exhibits spontaneous mirror symmetry breaking. We show that our model spontaneously breaks mirror symmetry in various catalytic configurations that only involve a small number of catalyzed reactions and nothing else. Of particular importance is that mirror symmetry breaking occurs in our model without the need for single-step autocatalytis or mutual inhibition, which may be of relevance for prebiotic chemistry. |
format | Online Article Text |
id | pubmed-10279737 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-102797372023-06-21 Conditions for the origin of homochirality in primordial catalytic reaction networks Gagnon, Jean-Sébastien Hochberg, David Sci Rep Article We study the generation of homochirality in a general chemical model (based on the homogeneous, fully connected Smoluchowski aggregation-fragmentation model) that obeys thermodynamics and can be easily mapped onto known origin of life models (e.g. autocatalytic sets, hypercycles, etc.), with essential aspects of origin of life modeling taken into consideration. Using a combination of theoretical modeling and numerical simulations, we look for minimal conditions for which our general chemical model exhibits spontaneous mirror symmetry breaking. We show that our model spontaneously breaks mirror symmetry in various catalytic configurations that only involve a small number of catalyzed reactions and nothing else. Of particular importance is that mirror symmetry breaking occurs in our model without the need for single-step autocatalytis or mutual inhibition, which may be of relevance for prebiotic chemistry. Nature Publishing Group UK 2023-06-19 /pmc/articles/PMC10279737/ /pubmed/37336897 http://dx.doi.org/10.1038/s41598-023-36852-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Gagnon, Jean-Sébastien Hochberg, David Conditions for the origin of homochirality in primordial catalytic reaction networks |
title | Conditions for the origin of homochirality in primordial catalytic reaction networks |
title_full | Conditions for the origin of homochirality in primordial catalytic reaction networks |
title_fullStr | Conditions for the origin of homochirality in primordial catalytic reaction networks |
title_full_unstemmed | Conditions for the origin of homochirality in primordial catalytic reaction networks |
title_short | Conditions for the origin of homochirality in primordial catalytic reaction networks |
title_sort | conditions for the origin of homochirality in primordial catalytic reaction networks |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279737/ https://www.ncbi.nlm.nih.gov/pubmed/37336897 http://dx.doi.org/10.1038/s41598-023-36852-4 |
work_keys_str_mv | AT gagnonjeansebastien conditionsfortheoriginofhomochiralityinprimordialcatalyticreactionnetworks AT hochbergdavid conditionsfortheoriginofhomochiralityinprimordialcatalyticreactionnetworks |