Cargando…

Disruption of the sialic acid/Siglec-9 axis improves antibody-mediated neutrophil cytotoxicity towards tumor cells

Upregulation of surface expressed sialoglycans on tumor cells is one of the mechanisms which promote tumor growth and progression. Specifically, the interactions of sialic acids with sialic acid-binding immunoglobulin-like lectins (Siglecs) on lymphoid or myeloid cells transmit inhibitory signals an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lustig, Marta, Chan, Chilam, Jansen, J. H. Marco, Bräutigam, Maria, Kölling, Max A., Gehlert, Carina Lynn, Baumann, Niklas, Mester, Simone, Foss, Stian, Andersen, Jan Terje, Bastian, Lorenz, Sondermann, Peter, Peipp, Matthias, Burger, Renate, Leusen, Jeanette H. W., Valerius, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279866/ https://www.ncbi.nlm.nih.gov/pubmed/37346044 http://dx.doi.org/10.3389/fimmu.2023.1178817

Ejemplares similares

Sialic Acids on Tumor Cells Modulate IgA Therapy by Neutrophils via Inhibitory Receptors Siglec-7 and Siglec-9
por: Chan, Chilam, et al.
Publicado: (2023)

Corrigendum: Targeting myeloid checkpoint molecules in combination with antibody therapy: A novel anti-cancer strategy with IgA antibodies?
por: Chan, Chilam, et al.
Publicado: (2022)

Targeting Myeloid Checkpoint Molecules in Combination With Antibody Therapy: A Novel Anti-Cancer Strategy With IgA Antibodies?
por: Chan, Chilam, et al.
Publicado: (2022)

Myeloid checkpoint blockade improves killing of T-acute lymphoblastic leukemia cells by an IgA2 variant of daratumumab
por: Baumann, Niklas, et al.
Publicado: (2022)

Enhancement of epidermal growth factor receptor antibody tumor immunotherapy by glutaminyl cyclase inhibition to interfere with CD47/signal regulatory protein alpha interactions
por: Baumann, Niklas, et al.
Publicado: (2021)

Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9
por: Rodriguez, Ernesto, et al.
Publicado: (2021)

Modulation of Immune Tolerance via Siglec-Sialic Acid Interactions
por: Lübbers, Joyce, et al.
Publicado: (2018)

Discovery of a new sialic acid binding region that regulates Siglec-7
por: Yamakawa, Nao, et al.
Publicado: (2020)

Targeting the Siglec–Sialic Acid Immune Axis in Cancer: Current and Future Approaches
por: Läubli, Heinz, et al.
Publicado: (2022)

Siglecs Facilitate HIV-1 Infection of Macrophages through Adhesion with Viral Sialic Acids
por: Zou, Zhongcheng, et al.
Publicado: (2011)

Regulation of B Cell Functions by the Sialic Acid-Binding Receptors Siglec-G and CD22
por: Jellusova, Julia, et al.
Publicado: (2012)

Sialic acids siglec interaction: A unique strategy to circumvent innate immune response by pathogens
por: Khatua, Biswajit, et al.
Publicado: (2013)

Inhibitory Siglec-sialic acid interactions in balancing immunological activation and tolerance during viral infections
por: Saini, Pratima, et al.
Publicado: (2022)

Assessment of Sialic Acid Diversity in Cancer- and Non-Cancer Related CA125 Antigen Using Sialic Acid-Binding Ig-Like Lectins (Siglecs)
por: Mitic, N., et al.
Publicado: (2012)

Fc Engineering Strategies to Advance IgA Antibodies as Therapeutic Agents
por: van Tetering, Geert, et al.
Publicado: (2020)

Sialic Acid-Siglec Axis in Human Immune Regulation, Involvement in Autoimmunity and Cancer and Potential Therapeutic Treatments
por: Gianchecchi, Elena, et al.
Publicado: (2021)

Sialic acids acquired by Pseudomonas aeruginosa are involved in reduced complement deposition and siglec mediated host-cell recognition
por: Khatua, Biswajit, et al.
Publicado: (2010)

The Role of Sialic Acid-Binding Receptors (Siglecs) in the Immunomodulatory Effects of Trypanosoma cruzi Sialoglycoproteins on the Protective Immunity of the Host
por: Morrot, Alexandre
Publicado: (2013)

Sialic Acid-Siglec Axis as Molecular Checkpoints Targeting of Immune System: Smart Players in Pathology and Conventional Therapy
por: Wielgat, Przemyslaw, et al.
Publicado: (2020)

Anti-GD2 IgA kills tumors by neutrophils without antibody-associated pain in the preclinical treatment of high-risk neuroblastoma
por: Evers, Mitchell, et al.
Publicado: (2021)

Group B Streptococcus Engages an Inhibitory Siglec through Sialic Acid Mimicry to Blunt Innate Immune and Inflammatory Responses In Vivo
por: Chang, Yung-Chi, et al.
Publicado: (2014)

Leishmania donovani Utilize Sialic Acids for Binding and Phagocytosis in the Macrophages through Selective Utilization of Siglecs and Impair the Innate Immune Arm
por: Roy, Saptarshi, et al.
Publicado: (2016)

Sugar Free: Novel Immunotherapeutic Approaches Targeting Siglecs and Sialic Acids to Enhance Natural Killer Cell Cytotoxicity Against Cancer
por: Daly, John, et al.
Publicado: (2019)

Extended plasma half-life of albumin-binding domain fused human IgA upon pH-dependent albumin engagement of human FcRn in vitro and in vivo
por: Mester, Simone, et al.
Publicado: (2021)

Effect of a tail piece cysteine deletion on biochemical and functional properties of an epidermal growth factor receptor-directed IgA2 m(1) antibody
por: Brunke, Christina, et al.
Publicado: (2013)

A novel Fc-engineered human ICAM-1/CD54 antibody with potent anti-myeloma activity developed by cellular panning of phage display libraries
por: Klausz, Katja, et al.
Publicado: (2017)

Dual Fc optimization to increase the cytotoxic activity of a CD19-targeting antibody
por: Gehlert, Carina Lynn, et al.
Publicado: (2022)

Sialic Acid-Siglec-E Interactions During Pseudomonas aeruginosa Infection of Macrophages Interferes With Phagosome Maturation by Altering Intracellular Calcium Concentrations
por: Mukherjee, Kaustuv, et al.
Publicado: (2020)

Engineering of CD19 Antibodies: A CD19-TRAIL Fusion Construct Specifically Induces Apoptosis in B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Cells In Vivo
por: Winterberg, Dorothee, et al.
Publicado: (2021)

PolySialic acid-nanoparticles inhibit macrophage mediated inflammation through Siglec agonism: a potential treatment for age related macular degeneration
por: Krishnan, Anitha, et al.
Publicado: (2023)

Siglec Ligands
por: Gonzalez-Gil, Anabel, et al.
Publicado: (2021)

Molecular cloning of porcine Siglec-3, Siglec-5 and Siglec-10, and identification of Siglec-10 as an alternative receptor for porcine reproductive and respiratory syndrome virus (PRRSV)
por: Xie, Jiexiong, et al.
Publicado: (2017)

Coevolution of Siglec-11 and Siglec-16 via gene conversion in primates
por: Hayakawa, Toshiyuki, et al.
Publicado: (2017)

Siglecs at the Host–Pathogen Interface
por: Chang, Yung-Chi, et al.
Publicado: (2020)

Siglecs as Therapeutic Targets in Cancer
por: Lim, Jackwee, et al.
Publicado: (2021)

Siglec Signaling in the Tumor Microenvironment
por: van Houtum, Eline J. H., et al.
Publicado: (2021)

Dual intracellular targeting by ruxolitinib and the Mcl-1 inhibitor S63845 in interleukin-6-dependent myeloma cells blocks in vivo tumor growth
por: Burger, Renate, et al.
Publicado: (2021)

The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression
por: Zheng, Yayun, et al.
Publicado: (2020)

Exploring Alternative Radiolabeling Strategies for Sialic Acid-Binding Immunoglobulin-Like Lectin 9 Peptide: [(68)Ga]Ga- and [(18)F]AlF-NOTA-Siglec-9
por: Moisio, Olli, et al.
Publicado: (2018)

Interplay Between Sialic Acids, Siglec-E, and Neu1 Regulates MyD88- and TRIF-Dependent Pathways for TLR4-Activation During Leishmania donovani Infection
por: Karmakar, Joyshree, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_82h3b9isce5ggl4v8bcd2a52g5