Nuanced role for dendritic cell intrinsic IRE1 RNase in the regulation of antitumor adaptive immunity

In cancer, activation of the IRE1/XBP1s axis of the unfolded protein response (UPR) promotes immunosuppression and tumor growth, by acting in cancer cells and tumor infiltrating immune cells. However, the role of IRE1/XBP1s in dendritic cells (DCs) in tumors, particularly in conventional type 1 DCs...

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Detalles Bibliográficos
Autores principales: Flores-Santibañez, Felipe, Rennen, Sofie, Fernández, Dominique, De Nolf, Clint, Van De Velde, Evelien, Gaete González, Sandra, Fuentes, Camila, Moreno, Carolina, Figueroa, Diego, Lladser, Álvaro, Iwawaki, Takao, Bono, María Rosa, Janssens, Sophie, Osorio, Fabiola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279875/
https://www.ncbi.nlm.nih.gov/pubmed/37346037
http://dx.doi.org/10.3389/fimmu.2023.1209588

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