Cargando…

Brain structure–function coupling associated with cognitive impairment in cerebral small vessel disease

Cerebral small vessel disease (CSVD) is a common chronic and progressive disease that can lead to mental and cognitive impairment. Damage to brain structure and function may play an important role in the neuropsychiatric disorders of patients with CSVD. Increasing evidence suggests that functional c...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Na, Liang, Changhu, Zhang, Xinyue, Sui, Chaofan, Gao, Yian, Guo, Lingfei, Wen, Hongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279881/
https://www.ncbi.nlm.nih.gov/pubmed/37346086
http://dx.doi.org/10.3389/fnins.2023.1163274
_version_ 1785060684219809792
author Wang, Na
Liang, Changhu
Zhang, Xinyue
Sui, Chaofan
Gao, Yian
Guo, Lingfei
Wen, Hongwei
author_facet Wang, Na
Liang, Changhu
Zhang, Xinyue
Sui, Chaofan
Gao, Yian
Guo, Lingfei
Wen, Hongwei
author_sort Wang, Na
collection PubMed
description Cerebral small vessel disease (CSVD) is a common chronic and progressive disease that can lead to mental and cognitive impairment. Damage to brain structure and function may play an important role in the neuropsychiatric disorders of patients with CSVD. Increasing evidence suggests that functional changes are accompanied by structural changes in corresponding brain regions. Thus, normal structure–function coupling is essential for optimal brain performance, and disrupted structure–function coupling can be found in many neurological and psychiatric disorders. To date, most studies on patients with CSVD have focused on separate structures or functions, including reductions in white matter volume and blood flow, which lead to cognitive dysfunction. However, there are few studies on brain structure–function coupling in patients with CSVD. In recent years, with the rapid development of multilevel (voxel-wise, neurovascular, regional level, and network level) brain structure–functional coupling analysis methods based on multimodal magnetic resonance imaging (MRI), new evidence has been provided to reveal the correlation between brain function and structural abnormalities and cognitive impairment. Therefore, studying brain structure–function coupling has a potential significance in the exploration and elucidation of the neurobiological mechanism of cognitive impairment in patients with CSVD. This article mainly describes the currently popular brain structure–function coupling analysis technology based on multimodal MRI and the important research progress of these coupling technologies on CSVD and cognitive impairment to provide a perspective for the study of the pathogenesis and early diagnosis of CSVD.
format Online
Article
Text
id pubmed-10279881
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-102798812023-06-21 Brain structure–function coupling associated with cognitive impairment in cerebral small vessel disease Wang, Na Liang, Changhu Zhang, Xinyue Sui, Chaofan Gao, Yian Guo, Lingfei Wen, Hongwei Front Neurosci Neuroscience Cerebral small vessel disease (CSVD) is a common chronic and progressive disease that can lead to mental and cognitive impairment. Damage to brain structure and function may play an important role in the neuropsychiatric disorders of patients with CSVD. Increasing evidence suggests that functional changes are accompanied by structural changes in corresponding brain regions. Thus, normal structure–function coupling is essential for optimal brain performance, and disrupted structure–function coupling can be found in many neurological and psychiatric disorders. To date, most studies on patients with CSVD have focused on separate structures or functions, including reductions in white matter volume and blood flow, which lead to cognitive dysfunction. However, there are few studies on brain structure–function coupling in patients with CSVD. In recent years, with the rapid development of multilevel (voxel-wise, neurovascular, regional level, and network level) brain structure–functional coupling analysis methods based on multimodal magnetic resonance imaging (MRI), new evidence has been provided to reveal the correlation between brain function and structural abnormalities and cognitive impairment. Therefore, studying brain structure–function coupling has a potential significance in the exploration and elucidation of the neurobiological mechanism of cognitive impairment in patients with CSVD. This article mainly describes the currently popular brain structure–function coupling analysis technology based on multimodal MRI and the important research progress of these coupling technologies on CSVD and cognitive impairment to provide a perspective for the study of the pathogenesis and early diagnosis of CSVD. Frontiers Media S.A. 2023-06-06 /pmc/articles/PMC10279881/ /pubmed/37346086 http://dx.doi.org/10.3389/fnins.2023.1163274 Text en Copyright © 2023 Wang, Liang, Zhang, Sui, Gao, Guo and Wen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Wang, Na
Liang, Changhu
Zhang, Xinyue
Sui, Chaofan
Gao, Yian
Guo, Lingfei
Wen, Hongwei
Brain structure–function coupling associated with cognitive impairment in cerebral small vessel disease
title Brain structure–function coupling associated with cognitive impairment in cerebral small vessel disease
title_full Brain structure–function coupling associated with cognitive impairment in cerebral small vessel disease
title_fullStr Brain structure–function coupling associated with cognitive impairment in cerebral small vessel disease
title_full_unstemmed Brain structure–function coupling associated with cognitive impairment in cerebral small vessel disease
title_short Brain structure–function coupling associated with cognitive impairment in cerebral small vessel disease
title_sort brain structure–function coupling associated with cognitive impairment in cerebral small vessel disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279881/
https://www.ncbi.nlm.nih.gov/pubmed/37346086
http://dx.doi.org/10.3389/fnins.2023.1163274
work_keys_str_mv AT wangna brainstructurefunctioncouplingassociatedwithcognitiveimpairmentincerebralsmallvesseldisease
AT liangchanghu brainstructurefunctioncouplingassociatedwithcognitiveimpairmentincerebralsmallvesseldisease
AT zhangxinyue brainstructurefunctioncouplingassociatedwithcognitiveimpairmentincerebralsmallvesseldisease
AT suichaofan brainstructurefunctioncouplingassociatedwithcognitiveimpairmentincerebralsmallvesseldisease
AT gaoyian brainstructurefunctioncouplingassociatedwithcognitiveimpairmentincerebralsmallvesseldisease
AT guolingfei brainstructurefunctioncouplingassociatedwithcognitiveimpairmentincerebralsmallvesseldisease
AT wenhongwei brainstructurefunctioncouplingassociatedwithcognitiveimpairmentincerebralsmallvesseldisease