Conformational changes in protein kinase A along its activation cycle are rooted in the folding energetics of cyclic-nucleotide binding domains

Cyclic-nucleotide binding (CNB) domains are structurally and evolutionarily conserved signaling modules that regulate proteins with diverse folds and functions. Despite a wealth of structural information, the mechanisms by which CNB domains couple cyclic-nucleotide binding to conformational changes...

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Detalles Bibliográficos
Autores principales: Chau, Amy K., Bracken, Katherine, Bai, Lihui, Pham, Dominic, Good, Lydia L., Maillard, Rodrigo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279917/
https://www.ncbi.nlm.nih.gov/pubmed/37150322
http://dx.doi.org/10.1016/j.jbc.2023.104790

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