Neurostimulation as a Putative Method for the Treatment of Drug-resistant Epilepsy in Patient and Animal Models of Epilepsy

A patient with epilepsy was shown to have neurobiological, psychological, cognitive, and social issues as a result of recurring seizures, which is regarded as a chronic brain disease. However, despite numerous drug treatments, approximately, 30%–40% of all patients are resistant to antiepileptic dru...

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Autores principales: Bakhtiarzadeh, Fatemeh, Zare, Meysam, Ghasemi, Zahra, Dehghan, Samaneh, Sadeghin, Azam, Joghataei, Mohammad Taghi, Ahmadirad, Nooshin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Neuroscience Society 2023
Materias:
Review Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279981/
https://www.ncbi.nlm.nih.gov/pubmed/37346878
http://dx.doi.org/10.32598/bcn.2022.2360.4
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author Bakhtiarzadeh, Fatemeh
Zare, Meysam
Ghasemi, Zahra
Dehghan, Samaneh
Sadeghin, Azam
Joghataei, Mohammad Taghi
Ahmadirad, Nooshin
author_facet Bakhtiarzadeh, Fatemeh
Zare, Meysam
Ghasemi, Zahra
Dehghan, Samaneh
Sadeghin, Azam
Joghataei, Mohammad Taghi
Ahmadirad, Nooshin
author_sort Bakhtiarzadeh, Fatemeh
collection PubMed
description A patient with epilepsy was shown to have neurobiological, psychological, cognitive, and social issues as a result of recurring seizures, which is regarded as a chronic brain disease. However, despite numerous drug treatments, approximately, 30%–40% of all patients are resistant to antiepileptic drugs. Therefore, newer therapeutic modalities are introduced into clinical practice which involve neurostimulation and direct stimulation of the brain. Hence, we review published literature on vagus nerve stimulation, trigeminal nerve stimulation, applying responsive stimulation systems, and deep brain stimulation (DBS) in animals and epileptic patient with an emphasis on drug-resistant epilepsy.
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spelling pubmed-102799812023-06-21 Neurostimulation as a Putative Method for the Treatment of Drug-resistant Epilepsy in Patient and Animal Models of Epilepsy Bakhtiarzadeh, Fatemeh Zare, Meysam Ghasemi, Zahra Dehghan, Samaneh Sadeghin, Azam Joghataei, Mohammad Taghi Ahmadirad, Nooshin Basic Clin Neurosci Review Paper A patient with epilepsy was shown to have neurobiological, psychological, cognitive, and social issues as a result of recurring seizures, which is regarded as a chronic brain disease. However, despite numerous drug treatments, approximately, 30%–40% of all patients are resistant to antiepileptic drugs. Therefore, newer therapeutic modalities are introduced into clinical practice which involve neurostimulation and direct stimulation of the brain. Hence, we review published literature on vagus nerve stimulation, trigeminal nerve stimulation, applying responsive stimulation systems, and deep brain stimulation (DBS) in animals and epileptic patient with an emphasis on drug-resistant epilepsy. Iranian Neuroscience Society 2023 2023-01-01 /pmc/articles/PMC10279981/ /pubmed/37346878 http://dx.doi.org/10.32598/bcn.2022.2360.4 Text en Copyright© 2023 Iranian Neuroscience Society https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Review Paper
Bakhtiarzadeh, Fatemeh
Zare, Meysam
Ghasemi, Zahra
Dehghan, Samaneh
Sadeghin, Azam
Joghataei, Mohammad Taghi
Ahmadirad, Nooshin
Neurostimulation as a Putative Method for the Treatment of Drug-resistant Epilepsy in Patient and Animal Models of Epilepsy
title Neurostimulation as a Putative Method for the Treatment of Drug-resistant Epilepsy in Patient and Animal Models of Epilepsy
title_full Neurostimulation as a Putative Method for the Treatment of Drug-resistant Epilepsy in Patient and Animal Models of Epilepsy
title_fullStr Neurostimulation as a Putative Method for the Treatment of Drug-resistant Epilepsy in Patient and Animal Models of Epilepsy
title_full_unstemmed Neurostimulation as a Putative Method for the Treatment of Drug-resistant Epilepsy in Patient and Animal Models of Epilepsy
title_short Neurostimulation as a Putative Method for the Treatment of Drug-resistant Epilepsy in Patient and Animal Models of Epilepsy
title_sort neurostimulation as a putative method for the treatment of drug-resistant epilepsy in patient and animal models of epilepsy
topic Review Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10279981/
https://www.ncbi.nlm.nih.gov/pubmed/37346878
http://dx.doi.org/10.32598/bcn.2022.2360.4
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