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Neopeltolide and its synthetic derivatives: a promising new class of anticancer agents

Being the first or second cause of death worldwide, cancer represents the most significant clinical, social, and financial burden of any human illness. Despite recent progresses in cancer diagnosis and management, traditional cancer chemotherapies have shown several adverse side effects and loss of...

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Autores principales: Peña-Corona, Sheila I., Hernández-Parra, Héctor, Bernal-Chávez, Sergio A., Mendoza-Muñoz, Néstor, Romero-Montero, Alejandra, Del Prado-Audelo, María Luisa, Cortés, Hernán, Ateşşahin, Dilek Arslan, Habtemariam, Solomon, Almarhoon, Zainab M., Abdull Razis, Ahmad Faizal, Modu, Babagana, Sharifi-Rad, Javad, Leyva-Gómez, Gerardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280003/
https://www.ncbi.nlm.nih.gov/pubmed/37346293
http://dx.doi.org/10.3389/fphar.2023.1206334
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author Peña-Corona, Sheila I.
Hernández-Parra, Héctor
Bernal-Chávez, Sergio A.
Mendoza-Muñoz, Néstor
Romero-Montero, Alejandra
Del Prado-Audelo, María Luisa
Cortés, Hernán
Ateşşahin, Dilek Arslan
Habtemariam, Solomon
Almarhoon, Zainab M.
Abdull Razis, Ahmad Faizal
Modu, Babagana
Sharifi-Rad, Javad
Leyva-Gómez, Gerardo
author_facet Peña-Corona, Sheila I.
Hernández-Parra, Héctor
Bernal-Chávez, Sergio A.
Mendoza-Muñoz, Néstor
Romero-Montero, Alejandra
Del Prado-Audelo, María Luisa
Cortés, Hernán
Ateşşahin, Dilek Arslan
Habtemariam, Solomon
Almarhoon, Zainab M.
Abdull Razis, Ahmad Faizal
Modu, Babagana
Sharifi-Rad, Javad
Leyva-Gómez, Gerardo
author_sort Peña-Corona, Sheila I.
collection PubMed
description Being the first or second cause of death worldwide, cancer represents the most significant clinical, social, and financial burden of any human illness. Despite recent progresses in cancer diagnosis and management, traditional cancer chemotherapies have shown several adverse side effects and loss of potency due to increased resistance. As a result, one of the current approaches is on with the search of bioactive anticancer compounds from natural sources. Neopeltolide is a marine-derived macrolide isolated from deep-water sponges collected off Jamaica’s north coast. Its mechanism of action is still under research but represents a potentially promising novel drug for cancer therapy. In this review, we first illustrate the general structural characterization of neopeltolide, the semi-synthetic derivatives, and current medical applications. In addition, we reviewed its anticancer properties, primarily based on in vitro studies, and the possible clinical trials. Finally, we summarize the recent progress in the mechanism of antitumor action of neopeltolide. According to the information presented, we identified two principal challenges in the research, i) the effective dose which acts neopeltolide as an anticancer compound, and ii) to unequivocally establish the mechanism of action by which the compound exerts its antiproliferative effect.
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spelling pubmed-102800032023-06-21 Neopeltolide and its synthetic derivatives: a promising new class of anticancer agents Peña-Corona, Sheila I. Hernández-Parra, Héctor Bernal-Chávez, Sergio A. Mendoza-Muñoz, Néstor Romero-Montero, Alejandra Del Prado-Audelo, María Luisa Cortés, Hernán Ateşşahin, Dilek Arslan Habtemariam, Solomon Almarhoon, Zainab M. Abdull Razis, Ahmad Faizal Modu, Babagana Sharifi-Rad, Javad Leyva-Gómez, Gerardo Front Pharmacol Pharmacology Being the first or second cause of death worldwide, cancer represents the most significant clinical, social, and financial burden of any human illness. Despite recent progresses in cancer diagnosis and management, traditional cancer chemotherapies have shown several adverse side effects and loss of potency due to increased resistance. As a result, one of the current approaches is on with the search of bioactive anticancer compounds from natural sources. Neopeltolide is a marine-derived macrolide isolated from deep-water sponges collected off Jamaica’s north coast. Its mechanism of action is still under research but represents a potentially promising novel drug for cancer therapy. In this review, we first illustrate the general structural characterization of neopeltolide, the semi-synthetic derivatives, and current medical applications. In addition, we reviewed its anticancer properties, primarily based on in vitro studies, and the possible clinical trials. Finally, we summarize the recent progress in the mechanism of antitumor action of neopeltolide. According to the information presented, we identified two principal challenges in the research, i) the effective dose which acts neopeltolide as an anticancer compound, and ii) to unequivocally establish the mechanism of action by which the compound exerts its antiproliferative effect. Frontiers Media S.A. 2023-06-06 /pmc/articles/PMC10280003/ /pubmed/37346293 http://dx.doi.org/10.3389/fphar.2023.1206334 Text en Copyright © 2023 Peña-Corona, Hernández-Parra, Bernal-Chávez, Mendoza-Muñoz, Romero-Montero, Del Prado-Audelo, Cortés, Ateşşahin, Habtemariam, Almarhoon, Abdull Razis, Modu, Sharifi-Rad and Leyva-Gómez. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Peña-Corona, Sheila I.
Hernández-Parra, Héctor
Bernal-Chávez, Sergio A.
Mendoza-Muñoz, Néstor
Romero-Montero, Alejandra
Del Prado-Audelo, María Luisa
Cortés, Hernán
Ateşşahin, Dilek Arslan
Habtemariam, Solomon
Almarhoon, Zainab M.
Abdull Razis, Ahmad Faizal
Modu, Babagana
Sharifi-Rad, Javad
Leyva-Gómez, Gerardo
Neopeltolide and its synthetic derivatives: a promising new class of anticancer agents
title Neopeltolide and its synthetic derivatives: a promising new class of anticancer agents
title_full Neopeltolide and its synthetic derivatives: a promising new class of anticancer agents
title_fullStr Neopeltolide and its synthetic derivatives: a promising new class of anticancer agents
title_full_unstemmed Neopeltolide and its synthetic derivatives: a promising new class of anticancer agents
title_short Neopeltolide and its synthetic derivatives: a promising new class of anticancer agents
title_sort neopeltolide and its synthetic derivatives: a promising new class of anticancer agents
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280003/
https://www.ncbi.nlm.nih.gov/pubmed/37346293
http://dx.doi.org/10.3389/fphar.2023.1206334
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