Non-peptide compounds from Kronopolites svenhedini (Verhoeff) and their antitumor and iNOS inhibitory activities

Six new compounds, including a tetralone 1, two xanthones 2 and 3, a flavan derivative 4, and two nor-diterpenoids 7 and 8, accompanied by two known flavan derivatives 5 and 6 and a known olefine acid (9) were isolated from whole bodies of Kronopolites svenhedini (Verhoeff). The structures of the ne...

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Autores principales: Yuan, Yuan-Nan, Li, Jin-Qiang, Fang, Hong-Bin, Xing, Shao-Jun, Yan, Yong-Ming, Cheng, Yong-Xian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2023
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280063/
https://www.ncbi.nlm.nih.gov/pubmed/37346495
http://dx.doi.org/10.3762/bjoc.19.59
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author Yuan, Yuan-Nan
Li, Jin-Qiang
Fang, Hong-Bin
Xing, Shao-Jun
Yan, Yong-Ming
Cheng, Yong-Xian
author_facet Yuan, Yuan-Nan
Li, Jin-Qiang
Fang, Hong-Bin
Xing, Shao-Jun
Yan, Yong-Ming
Cheng, Yong-Xian
author_sort Yuan, Yuan-Nan
collection PubMed
description Six new compounds, including a tetralone 1, two xanthones 2 and 3, a flavan derivative 4, and two nor-diterpenoids 7 and 8, accompanied by two known flavan derivatives 5 and 6 and a known olefine acid (9) were isolated from whole bodies of Kronopolites svenhedini (Verhoeff). The structures of the new compounds were determined by 1D and 2D nuclear magnetic resonance (NMR) and other spectroscopic methods, as well as computational methods. Selected compounds were evaluated for their biological properties against a mouse pancreatic cancer cell line and inhibitory effects on iNOS and COX-2 in RAW264.7 cells.
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spelling pubmed-102800632023-06-21 Non-peptide compounds from Kronopolites svenhedini (Verhoeff) and their antitumor and iNOS inhibitory activities Yuan, Yuan-Nan Li, Jin-Qiang Fang, Hong-Bin Xing, Shao-Jun Yan, Yong-Ming Cheng, Yong-Xian Beilstein J Org Chem Full Research Paper Six new compounds, including a tetralone 1, two xanthones 2 and 3, a flavan derivative 4, and two nor-diterpenoids 7 and 8, accompanied by two known flavan derivatives 5 and 6 and a known olefine acid (9) were isolated from whole bodies of Kronopolites svenhedini (Verhoeff). The structures of the new compounds were determined by 1D and 2D nuclear magnetic resonance (NMR) and other spectroscopic methods, as well as computational methods. Selected compounds were evaluated for their biological properties against a mouse pancreatic cancer cell line and inhibitory effects on iNOS and COX-2 in RAW264.7 cells. Beilstein-Institut 2023-06-07 /pmc/articles/PMC10280063/ /pubmed/37346495 http://dx.doi.org/10.3762/bjoc.19.59 Text en Copyright © 2023, Yuan et al. https://creativecommons.org/licenses/by/4.0/This is an open access article licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-journals.org/bjoc/terms/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this article could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material.
spellingShingle Full Research Paper
Yuan, Yuan-Nan
Li, Jin-Qiang
Fang, Hong-Bin
Xing, Shao-Jun
Yan, Yong-Ming
Cheng, Yong-Xian
Non-peptide compounds from Kronopolites svenhedini (Verhoeff) and their antitumor and iNOS inhibitory activities
title Non-peptide compounds from Kronopolites svenhedini (Verhoeff) and their antitumor and iNOS inhibitory activities
title_full Non-peptide compounds from Kronopolites svenhedini (Verhoeff) and their antitumor and iNOS inhibitory activities
title_fullStr Non-peptide compounds from Kronopolites svenhedini (Verhoeff) and their antitumor and iNOS inhibitory activities
title_full_unstemmed Non-peptide compounds from Kronopolites svenhedini (Verhoeff) and their antitumor and iNOS inhibitory activities
title_short Non-peptide compounds from Kronopolites svenhedini (Verhoeff) and their antitumor and iNOS inhibitory activities
title_sort non-peptide compounds from kronopolites svenhedini (verhoeff) and their antitumor and inos inhibitory activities
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280063/
https://www.ncbi.nlm.nih.gov/pubmed/37346495
http://dx.doi.org/10.3762/bjoc.19.59
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