The impact of nucleoside base modification in mRNA vaccine is influenced by the chemistry of its lipid nanoparticle delivery system

The use of modified nucleosides is an important approach to mitigate the intrinsic immunostimulatory activity of exogenous mRNA and to increase its translation for mRNA therapeutic applications. However, for vaccine applications, the intrinsic immunostimulatory nature of unmodified mRNA could help i...

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Detalles Bibliográficos
Autores principales: Bernard, Marie-Clotilde, Bazin, Emilie, Petiot, Nadine, Lemdani, Katia, Commandeur, Sylvie, Verdelet, Cécile, Margot, Sylvie, Perkov, Vladimir, Ripoll, Manon, Garinot, Marie, Ruiz, Sophie, Boudet, Florence, Rokbi, Bachra, Haensler, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280092/
https://www.ncbi.nlm.nih.gov/pubmed/37346973
http://dx.doi.org/10.1016/j.omtn.2023.05.004

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