Lipid nanoparticle-encapsulated, chemically modified anti-adenoviral siRNAs inhibit hepatic adenovirus infection in immunosuppressed Syrian hamsters

RNA interference has demonstrated its potential as an antiviral therapy for treatment of human adenovirus (hAd) infections. The only existing viral vector-based system for delivery of anti-adenoviral artificial microRNAs available for in vivo use, however, has proven to be inefficient in therapeutic...

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Detalles Bibliográficos
Autores principales: Geisler, Anja, Dieringer, Babette, Elsner, Leslie, Klingel, Karin, Klopfleisch, Robert, Vornlocher, Hans-Peter, Kurreck, Jens, Fechner, Henry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280093/
https://www.ncbi.nlm.nih.gov/pubmed/37346978
http://dx.doi.org/10.1016/j.omtn.2023.05.016

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