DNA damage‐induced cellular senescence is regulated by 53BP1 accumulation in the nuclear foci and phase separation

Cellular senescence is linked to a wide range of age‐related diseases and can be triggered by a variety of stresses, including DNA damage. A variety of genotoxic stressors, such as anti‐cancer drugs, cause DNA double‐strand breaks (DSBs), which trigger the accumulation of the tumour suppressor prote...

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Detalles Bibliográficos
Autores principales: Oda, Tsukasa, Gotoh, Nanami, Kasamatsu, Tetsuhiro, Handa, Hiroshi, Saitoh, Takayuki, Sasaki, Nobuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280147/
https://www.ncbi.nlm.nih.gov/pubmed/36642815
http://dx.doi.org/10.1111/cpr.13398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280147/
https://www.ncbi.nlm.nih.gov/pubmed/36642815
http://dx.doi.org/10.1111/cpr.13398

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