Strategic self-limiting production of infectious HIV particles by CRISPR in permissive cells

Post-translational glycosylation of the HIV-1 envelope protein involving precursor glycan trimming by mannosyl oligosaccharide glucosidase (MOGS) is critically important for morphogenesis of virions and viral entry. Strategic editing of the MOGS gene in T lymphocytes and myeloid origin cells harbori...

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Detalles Bibliográficos
Autores principales: Liu, Hong, Chen, Chen, Liao, Shuren, Sohaii, Danielle K., Cruz, Conrad R.Y., Burdo, Tricia H., Cradick, Thomas J., Mehta, Anand, Barrero, Carlos, Florez, Magda, Gordon, Jennifer, Grauzam, Stephane, Dressman, James, Amini, Shohreh, Bollard, Catherine M., Kaminski, Rafal, Khalili, Kamel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280355/
https://www.ncbi.nlm.nih.gov/pubmed/37346975
http://dx.doi.org/10.1016/j.omtn.2023.04.027

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