Case Report: Early detection of lung carcinoid in an asymptomatic individual by blood-test initiated PET-CT imaging

We present the case of a 53-year-old woman who was diagnosed with early-stage lung cancer by targeted cancer screening consisting of an immunological biopsy-based blood test followed by radiological imaging. The PanTum Detect blood test detects the biomarkers Apo10/DNaseX and Transketolase-like 1 (T...

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Autores principales: Burg, Simon, Smeets, Ralf, Gosau, Martin, Failing, Katja, Grust, Audrey Laure Céline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280377/
https://www.ncbi.nlm.nih.gov/pubmed/37346076
http://dx.doi.org/10.3389/fonc.2023.1177237
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author Burg, Simon
Smeets, Ralf
Gosau, Martin
Failing, Katja
Grust, Audrey Laure Céline
author_facet Burg, Simon
Smeets, Ralf
Gosau, Martin
Failing, Katja
Grust, Audrey Laure Céline
author_sort Burg, Simon
collection PubMed
description We present the case of a 53-year-old woman who was diagnosed with early-stage lung cancer by targeted cancer screening consisting of an immunological biopsy-based blood test followed by radiological imaging. The PanTum Detect blood test detects the biomarkers Apo10/DNaseX and Transketolase-like 1 (TKTL1) in circulating macrophage-like cells from peripheral blood samples to identify asymptomatic individuals with a high risk for malignancy. The elevated blood test values initiated an (18)F-FDG PET/CT visualization for further clarification. In this case, imaging indicated a lung carcinoma in the right upper lobe. A biopsy confirmed the presence of a lung carcinoma, which was removed surgically. Histologic examination revealed a typical I A2 carcinoid, which was completely removed, making further therapy obsolete.
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spelling pubmed-102803772023-06-21 Case Report: Early detection of lung carcinoid in an asymptomatic individual by blood-test initiated PET-CT imaging Burg, Simon Smeets, Ralf Gosau, Martin Failing, Katja Grust, Audrey Laure Céline Front Oncol Oncology We present the case of a 53-year-old woman who was diagnosed with early-stage lung cancer by targeted cancer screening consisting of an immunological biopsy-based blood test followed by radiological imaging. The PanTum Detect blood test detects the biomarkers Apo10/DNaseX and Transketolase-like 1 (TKTL1) in circulating macrophage-like cells from peripheral blood samples to identify asymptomatic individuals with a high risk for malignancy. The elevated blood test values initiated an (18)F-FDG PET/CT visualization for further clarification. In this case, imaging indicated a lung carcinoma in the right upper lobe. A biopsy confirmed the presence of a lung carcinoma, which was removed surgically. Histologic examination revealed a typical I A2 carcinoid, which was completely removed, making further therapy obsolete. Frontiers Media S.A. 2023-06-06 /pmc/articles/PMC10280377/ /pubmed/37346076 http://dx.doi.org/10.3389/fonc.2023.1177237 Text en Copyright © 2023 Burg, Smeets, Gosau, Failing and Grust https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Burg, Simon
Smeets, Ralf
Gosau, Martin
Failing, Katja
Grust, Audrey Laure Céline
Case Report: Early detection of lung carcinoid in an asymptomatic individual by blood-test initiated PET-CT imaging
title Case Report: Early detection of lung carcinoid in an asymptomatic individual by blood-test initiated PET-CT imaging
title_full Case Report: Early detection of lung carcinoid in an asymptomatic individual by blood-test initiated PET-CT imaging
title_fullStr Case Report: Early detection of lung carcinoid in an asymptomatic individual by blood-test initiated PET-CT imaging
title_full_unstemmed Case Report: Early detection of lung carcinoid in an asymptomatic individual by blood-test initiated PET-CT imaging
title_short Case Report: Early detection of lung carcinoid in an asymptomatic individual by blood-test initiated PET-CT imaging
title_sort case report: early detection of lung carcinoid in an asymptomatic individual by blood-test initiated pet-ct imaging
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280377/
https://www.ncbi.nlm.nih.gov/pubmed/37346076
http://dx.doi.org/10.3389/fonc.2023.1177237
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