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Oximetry at admission as a predictor of tomographic and functional impairment after 3–6 months in hospitalized patients with COVID-19

OBJECTIVE: To investigate characteristics that may be associated with radiologic and functional findings following discharge in patients with severe coronavirus disease 2019 (COVID-19). METHODS: This single-center, prospective, observational cohort study comprised patients aged >18 years who were...

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Autores principales: Villar, Pedro Maximink Esteves, Mendes, Paulo Roberto Araújo, Kiyota, Tatiana Alves, Engleitner, Henrique Alcântara, Tamesawa, Carolina Salem, Morello, Mayara Magalhães, Basso, Nayara Nobre, Arruda, Lucas Fileti, Vian, Bruna Scharlack, Ratti, Lígia dos Santos Roceto, de Oliveira, Laís Bacchin, Lima, Ana Lucia Cavallaro Baraúna, Ceccato, Hugo Dugolin, Silva, Julian Furtado, Villalba, Wander de Oliveira, Conterno, Lucieni de Oliveira, Resende, Mariângela Ribeiro, Pereira, Mônica Corso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280531/
https://www.ncbi.nlm.nih.gov/pubmed/37291854
http://dx.doi.org/10.1177/03000605231177187
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author Villar, Pedro Maximink Esteves
Mendes, Paulo Roberto Araújo
Kiyota, Tatiana Alves
Engleitner, Henrique Alcântara
Tamesawa, Carolina Salem
Morello, Mayara Magalhães
Basso, Nayara Nobre
Arruda, Lucas Fileti
Vian, Bruna Scharlack
Ratti, Lígia dos Santos Roceto
de Oliveira, Laís Bacchin
Lima, Ana Lucia Cavallaro Baraúna
Ceccato, Hugo Dugolin
Silva, Julian Furtado
Villalba, Wander de Oliveira
Conterno, Lucieni de Oliveira
Resende, Mariângela Ribeiro
Pereira, Mônica Corso
author_facet Villar, Pedro Maximink Esteves
Mendes, Paulo Roberto Araújo
Kiyota, Tatiana Alves
Engleitner, Henrique Alcântara
Tamesawa, Carolina Salem
Morello, Mayara Magalhães
Basso, Nayara Nobre
Arruda, Lucas Fileti
Vian, Bruna Scharlack
Ratti, Lígia dos Santos Roceto
de Oliveira, Laís Bacchin
Lima, Ana Lucia Cavallaro Baraúna
Ceccato, Hugo Dugolin
Silva, Julian Furtado
Villalba, Wander de Oliveira
Conterno, Lucieni de Oliveira
Resende, Mariângela Ribeiro
Pereira, Mônica Corso
author_sort Villar, Pedro Maximink Esteves
collection PubMed
description OBJECTIVE: To investigate characteristics that may be associated with radiologic and functional findings following discharge in patients with severe coronavirus disease 2019 (COVID-19). METHODS: This single-center, prospective, observational cohort study comprised patients aged >18 years who were hospitalized with COVID-19 pneumonia, between May and October 2020. After 3 to 6 months of discharge, patients were clinically evaluated and underwent spirometry, a 6-minute walk test (6MWT), and chest computed tomography (CT). Statistical analysis was performed using association and correlation tests. RESULTS: A total of 134 patients were included (25/114 [22%] were admitted with severe hypoxemia). On the follow-up chest CT, 29/92 (32%) had no abnormalities, regardless of the severity of the initial involvement, and the mean 6MWT distance was 447 m. Patients with desaturation on admission had an increased risk of remaining CT abnormalities: patients with SpO(2) between 88 and 92% had a 4.0-fold risk, and those with SpO(2) < 88% had a 6.2-fold risk. The group with SpO(2) < 88% also walked shorter distances than patients with SpO(2) between 88 and 92%. CONCLUSION: Initial hypoxemia was found to be a good predictor of persistent radiological abnormalities in follow-up and was associated with low performance in 6MWT.
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spelling pubmed-102805312023-06-21 Oximetry at admission as a predictor of tomographic and functional impairment after 3–6 months in hospitalized patients with COVID-19 Villar, Pedro Maximink Esteves Mendes, Paulo Roberto Araújo Kiyota, Tatiana Alves Engleitner, Henrique Alcântara Tamesawa, Carolina Salem Morello, Mayara Magalhães Basso, Nayara Nobre Arruda, Lucas Fileti Vian, Bruna Scharlack Ratti, Lígia dos Santos Roceto de Oliveira, Laís Bacchin Lima, Ana Lucia Cavallaro Baraúna Ceccato, Hugo Dugolin Silva, Julian Furtado Villalba, Wander de Oliveira Conterno, Lucieni de Oliveira Resende, Mariângela Ribeiro Pereira, Mônica Corso J Int Med Res Prospective Clinical Research Report OBJECTIVE: To investigate characteristics that may be associated with radiologic and functional findings following discharge in patients with severe coronavirus disease 2019 (COVID-19). METHODS: This single-center, prospective, observational cohort study comprised patients aged >18 years who were hospitalized with COVID-19 pneumonia, between May and October 2020. After 3 to 6 months of discharge, patients were clinically evaluated and underwent spirometry, a 6-minute walk test (6MWT), and chest computed tomography (CT). Statistical analysis was performed using association and correlation tests. RESULTS: A total of 134 patients were included (25/114 [22%] were admitted with severe hypoxemia). On the follow-up chest CT, 29/92 (32%) had no abnormalities, regardless of the severity of the initial involvement, and the mean 6MWT distance was 447 m. Patients with desaturation on admission had an increased risk of remaining CT abnormalities: patients with SpO(2) between 88 and 92% had a 4.0-fold risk, and those with SpO(2) < 88% had a 6.2-fold risk. The group with SpO(2) < 88% also walked shorter distances than patients with SpO(2) between 88 and 92%. CONCLUSION: Initial hypoxemia was found to be a good predictor of persistent radiological abnormalities in follow-up and was associated with low performance in 6MWT. SAGE Publications 2023-06-09 /pmc/articles/PMC10280531/ /pubmed/37291854 http://dx.doi.org/10.1177/03000605231177187 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Prospective Clinical Research Report
Villar, Pedro Maximink Esteves
Mendes, Paulo Roberto Araújo
Kiyota, Tatiana Alves
Engleitner, Henrique Alcântara
Tamesawa, Carolina Salem
Morello, Mayara Magalhães
Basso, Nayara Nobre
Arruda, Lucas Fileti
Vian, Bruna Scharlack
Ratti, Lígia dos Santos Roceto
de Oliveira, Laís Bacchin
Lima, Ana Lucia Cavallaro Baraúna
Ceccato, Hugo Dugolin
Silva, Julian Furtado
Villalba, Wander de Oliveira
Conterno, Lucieni de Oliveira
Resende, Mariângela Ribeiro
Pereira, Mônica Corso
Oximetry at admission as a predictor of tomographic and functional impairment after 3–6 months in hospitalized patients with COVID-19
title Oximetry at admission as a predictor of tomographic and functional impairment after 3–6 months in hospitalized patients with COVID-19
title_full Oximetry at admission as a predictor of tomographic and functional impairment after 3–6 months in hospitalized patients with COVID-19
title_fullStr Oximetry at admission as a predictor of tomographic and functional impairment after 3–6 months in hospitalized patients with COVID-19
title_full_unstemmed Oximetry at admission as a predictor of tomographic and functional impairment after 3–6 months in hospitalized patients with COVID-19
title_short Oximetry at admission as a predictor of tomographic and functional impairment after 3–6 months in hospitalized patients with COVID-19
title_sort oximetry at admission as a predictor of tomographic and functional impairment after 3–6 months in hospitalized patients with covid-19
topic Prospective Clinical Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280531/
https://www.ncbi.nlm.nih.gov/pubmed/37291854
http://dx.doi.org/10.1177/03000605231177187
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