Essential role of bromodomain proteins in renal cell carcinoma (Review)

Histone alterations are a hallmark of kidney cancer. Histone acetylation modification mediated by bromodomain proteins (BRD) has been indicated to be related to a variety of cancer types and several targeted inhibitors have been proven to be promising modalities for cancer adjuvant therapy. As renal...

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Autores principales: Wen, Qianghai, Liu, Haicheng, Lou, Kecheng, Zhang, Xing, Chao, Wei, Xin, Jianhui, Gong, Jiaxiang, Zou, Junrong, Zou, Xiaofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280547/
https://www.ncbi.nlm.nih.gov/pubmed/37293842
http://dx.doi.org/10.3892/mmr.2023.13026
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author Wen, Qianghai
Liu, Haicheng
Lou, Kecheng
Zhang, Xing
Chao, Wei
Xin, Jianhui
Gong, Jiaxiang
Zou, Junrong
Zou, Xiaofeng
author_facet Wen, Qianghai
Liu, Haicheng
Lou, Kecheng
Zhang, Xing
Chao, Wei
Xin, Jianhui
Gong, Jiaxiang
Zou, Junrong
Zou, Xiaofeng
author_sort Wen, Qianghai
collection PubMed
description Histone alterations are a hallmark of kidney cancer. Histone acetylation modification mediated by bromodomain proteins (BRD) has been indicated to be related to a variety of cancer types and several targeted inhibitors have been proven to be promising modalities for cancer adjuvant therapy. As renal cell carcinoma (RCC) is not sensitive to radiotherapy or chemotherapy, the exploration of effective adjuvant therapies remains an important research direction for advanced RCC. At present, studies on bromodomain family proteins in RCC are limited and the roles of bromodomain family proteins in RCC have remained to be fully elucidated. The present review discussed the role of bromodomain family proteins in RCC, aiming to explore possible potential therapeutic targets of BRD-related drugs in this type of cancer.
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spelling pubmed-102805472023-06-21 Essential role of bromodomain proteins in renal cell carcinoma (Review) Wen, Qianghai Liu, Haicheng Lou, Kecheng Zhang, Xing Chao, Wei Xin, Jianhui Gong, Jiaxiang Zou, Junrong Zou, Xiaofeng Mol Med Rep Review Histone alterations are a hallmark of kidney cancer. Histone acetylation modification mediated by bromodomain proteins (BRD) has been indicated to be related to a variety of cancer types and several targeted inhibitors have been proven to be promising modalities for cancer adjuvant therapy. As renal cell carcinoma (RCC) is not sensitive to radiotherapy or chemotherapy, the exploration of effective adjuvant therapies remains an important research direction for advanced RCC. At present, studies on bromodomain family proteins in RCC are limited and the roles of bromodomain family proteins in RCC have remained to be fully elucidated. The present review discussed the role of bromodomain family proteins in RCC, aiming to explore possible potential therapeutic targets of BRD-related drugs in this type of cancer. D.A. Spandidos 2023-06-08 /pmc/articles/PMC10280547/ /pubmed/37293842 http://dx.doi.org/10.3892/mmr.2023.13026 Text en Copyright: © Wen et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Wen, Qianghai
Liu, Haicheng
Lou, Kecheng
Zhang, Xing
Chao, Wei
Xin, Jianhui
Gong, Jiaxiang
Zou, Junrong
Zou, Xiaofeng
Essential role of bromodomain proteins in renal cell carcinoma (Review)
title Essential role of bromodomain proteins in renal cell carcinoma (Review)
title_full Essential role of bromodomain proteins in renal cell carcinoma (Review)
title_fullStr Essential role of bromodomain proteins in renal cell carcinoma (Review)
title_full_unstemmed Essential role of bromodomain proteins in renal cell carcinoma (Review)
title_short Essential role of bromodomain proteins in renal cell carcinoma (Review)
title_sort essential role of bromodomain proteins in renal cell carcinoma (review)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280547/
https://www.ncbi.nlm.nih.gov/pubmed/37293842
http://dx.doi.org/10.3892/mmr.2023.13026
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