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Chromosome instability‐associated prognostic signature and cluster investigation for cutaneous melanoma cases

Chromosomal instability (CIN) is closely associated to the early detection of several clinical tumours. In this study, the authors first established a novel prognostic model of melanoma using the hub genes of CIN, based on the datasets of The cancer genome atlas‐skin cutaneous melanoma (TCGA‐SKCM) a...

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Detalles Bibliográficos
Autores principales: Liu, Ning, Liu, Guangjing, Ma, Qian, Li, Xiaobing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280610/
https://www.ncbi.nlm.nih.gov/pubmed/37186446
http://dx.doi.org/10.1049/syb2.12064
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author Liu, Ning
Liu, Guangjing
Ma, Qian
Li, Xiaobing
author_facet Liu, Ning
Liu, Guangjing
Ma, Qian
Li, Xiaobing
author_sort Liu, Ning
collection PubMed
description Chromosomal instability (CIN) is closely associated to the early detection of several clinical tumours. In this study, the authors first established a novel prognostic model of melanoma using the hub genes of CIN, based on the datasets of The cancer genome atlas‐skin cutaneous melanoma (TCGA‐SKCM) and GSE65904 cohorts. Based on the risk scores of our model, the disease‐specific survival (DSS) prognosis was worse in the high‐risk group. Combining risk score, stage, age, ulceration, and clark factors, a Nomogram was generated to predict 1, 3, 5‐year survival rates, which indicated a good clinical validity. Our finding also showed a correlation between high/low risk and tumour infiltration levels of ‘activated CD8 T cells’ and ‘effector memory CD8 T cells’. Moreover, the authors first performed a CIN‐based tumour clustering analysis using TCGA‐SKCM cases, and identified two melanoma clusters, which exhibit the distinct DSS prognosis and the tumour‐infiltrating levels of CD8 T cells. Taken together, a promising CIN‐related prognostic signature and clustering for melanoma cases were first established in our study.
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spelling pubmed-102806102023-06-21 Chromosome instability‐associated prognostic signature and cluster investigation for cutaneous melanoma cases Liu, Ning Liu, Guangjing Ma, Qian Li, Xiaobing IET Syst Biol Original Research Chromosomal instability (CIN) is closely associated to the early detection of several clinical tumours. In this study, the authors first established a novel prognostic model of melanoma using the hub genes of CIN, based on the datasets of The cancer genome atlas‐skin cutaneous melanoma (TCGA‐SKCM) and GSE65904 cohorts. Based on the risk scores of our model, the disease‐specific survival (DSS) prognosis was worse in the high‐risk group. Combining risk score, stage, age, ulceration, and clark factors, a Nomogram was generated to predict 1, 3, 5‐year survival rates, which indicated a good clinical validity. Our finding also showed a correlation between high/low risk and tumour infiltration levels of ‘activated CD8 T cells’ and ‘effector memory CD8 T cells’. Moreover, the authors first performed a CIN‐based tumour clustering analysis using TCGA‐SKCM cases, and identified two melanoma clusters, which exhibit the distinct DSS prognosis and the tumour‐infiltrating levels of CD8 T cells. Taken together, a promising CIN‐related prognostic signature and clustering for melanoma cases were first established in our study. John Wiley and Sons Inc. 2023-04-25 /pmc/articles/PMC10280610/ /pubmed/37186446 http://dx.doi.org/10.1049/syb2.12064 Text en © 2023 The Authors. IET Systems Biology published by John Wiley & Sons Ltd on behalf of The Institution of Engineering and Technology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Liu, Ning
Liu, Guangjing
Ma, Qian
Li, Xiaobing
Chromosome instability‐associated prognostic signature and cluster investigation for cutaneous melanoma cases
title Chromosome instability‐associated prognostic signature and cluster investigation for cutaneous melanoma cases
title_full Chromosome instability‐associated prognostic signature and cluster investigation for cutaneous melanoma cases
title_fullStr Chromosome instability‐associated prognostic signature and cluster investigation for cutaneous melanoma cases
title_full_unstemmed Chromosome instability‐associated prognostic signature and cluster investigation for cutaneous melanoma cases
title_short Chromosome instability‐associated prognostic signature and cluster investigation for cutaneous melanoma cases
title_sort chromosome instability‐associated prognostic signature and cluster investigation for cutaneous melanoma cases
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280610/
https://www.ncbi.nlm.nih.gov/pubmed/37186446
http://dx.doi.org/10.1049/syb2.12064
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