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Fibrilación auricular y deterioro cognitivo: una revisión narrativa
INTRODUCTION. Atrial fibrillation (AF) is the most common arrhythmia in clinical practice and its incidence and prevalence increase with age, as does cognitive impairment (CI). DEVELOPMENT. Prospective observational studies have shown that AF can significantly increase the risk of stroke, which is a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Viguera Editores (Evidenze Group)
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280770/ https://www.ncbi.nlm.nih.gov/pubmed/36354300 http://dx.doi.org/10.33588/rn.7510.2022252 |
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author | Morales-Bacas, Elena Duque-Holguera, María Portilla-Cuenca, Juan C. Casado-Naranjo, Ignacio |
author_facet | Morales-Bacas, Elena Duque-Holguera, María Portilla-Cuenca, Juan C. Casado-Naranjo, Ignacio |
author_sort | Morales-Bacas, Elena |
collection | PubMed |
description | INTRODUCTION. Atrial fibrillation (AF) is the most common arrhythmia in clinical practice and its incidence and prevalence increase with age, as does cognitive impairment (CI). DEVELOPMENT. Prospective observational studies have shown that AF can significantly increase the risk of stroke, which is an important cause of CI, but it has also been established that the association between the two diseases may be independent of stroke and other shared risk factors. However, the pathophysiological mechanism linking the two entities is still unclear as it is likely to be a multifactorial process (cardioembolic silent strokes, proinflammatory states and cerebral hypoperfusion), with preliminary evidence of a link between atrial cardiomyopathy without AF and cognitive dysfunction. The association between AF and CI raises the possibility that therapeutic interventions aimed at managing this arrhythmia may prevent or delay the onset of CI. Anticoagulation has been shown to significantly reduce the risk of stroke in patients with AF and, with it, the risk of CI, but the effect of other therapeutic interventions such as rhythm and rate control is inconclusive. CONCLUSIONS. AF and CI are an important health problem worldwide and the demographic trend predicts exponential growth of both conditions in the coming years. Therefore, it seems necessary to increase our knowledge of the pathophysiological mechanisms related to them in order to establish effective preventive strategies. |
format | Online Article Text |
id | pubmed-10280770 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Viguera Editores (Evidenze Group) |
record_format | MEDLINE/PubMed |
spelling | pubmed-102807702023-06-21 Fibrilación auricular y deterioro cognitivo: una revisión narrativa Morales-Bacas, Elena Duque-Holguera, María Portilla-Cuenca, Juan C. Casado-Naranjo, Ignacio Rev Neurol Revisión INTRODUCTION. Atrial fibrillation (AF) is the most common arrhythmia in clinical practice and its incidence and prevalence increase with age, as does cognitive impairment (CI). DEVELOPMENT. Prospective observational studies have shown that AF can significantly increase the risk of stroke, which is an important cause of CI, but it has also been established that the association between the two diseases may be independent of stroke and other shared risk factors. However, the pathophysiological mechanism linking the two entities is still unclear as it is likely to be a multifactorial process (cardioembolic silent strokes, proinflammatory states and cerebral hypoperfusion), with preliminary evidence of a link between atrial cardiomyopathy without AF and cognitive dysfunction. The association between AF and CI raises the possibility that therapeutic interventions aimed at managing this arrhythmia may prevent or delay the onset of CI. Anticoagulation has been shown to significantly reduce the risk of stroke in patients with AF and, with it, the risk of CI, but the effect of other therapeutic interventions such as rhythm and rate control is inconclusive. CONCLUSIONS. AF and CI are an important health problem worldwide and the demographic trend predicts exponential growth of both conditions in the coming years. Therefore, it seems necessary to increase our knowledge of the pathophysiological mechanisms related to them in order to establish effective preventive strategies. Viguera Editores (Evidenze Group) 2022-11-16 /pmc/articles/PMC10280770/ /pubmed/36354300 http://dx.doi.org/10.33588/rn.7510.2022252 Text en Copyright: © Revista de Neurología https://creativecommons.org/licenses/by-nc-nd/4.0/Revista de Neurología trabaja bajo una licencia Creative Commons |
spellingShingle | Revisión Morales-Bacas, Elena Duque-Holguera, María Portilla-Cuenca, Juan C. Casado-Naranjo, Ignacio Fibrilación auricular y deterioro cognitivo: una revisión narrativa |
title | Fibrilación auricular y deterioro cognitivo: una revisión narrativa |
title_full | Fibrilación auricular y deterioro cognitivo: una revisión narrativa |
title_fullStr | Fibrilación auricular y deterioro cognitivo: una revisión narrativa |
title_full_unstemmed | Fibrilación auricular y deterioro cognitivo: una revisión narrativa |
title_short | Fibrilación auricular y deterioro cognitivo: una revisión narrativa |
title_sort | fibrilación auricular y deterioro cognitivo: una revisión narrativa |
topic | Revisión |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280770/ https://www.ncbi.nlm.nih.gov/pubmed/36354300 http://dx.doi.org/10.33588/rn.7510.2022252 |
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