The SARS-CoV-2 mutation landscape is shaped before replication starts

Mutation landscapes and signatures have been thoroughly studied in SARS-CoV-2. Here, we analyse those patterns and link their changes to the viral replication tissue in the respiratory tract. Surprisingly, a substantial difference in those patterns is observed in samples from vaccinated patients. He...

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Autores principales: Masone, Diego, Alvarez, Maria Soledad, Polo, Luis Mariano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2023
Materias:
Genomics and Bioinformatics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280802/
https://www.ncbi.nlm.nih.gov/pubmed/37338301
http://dx.doi.org/10.1590/1678-4685-GMB-2023-0005
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author Masone, Diego
Alvarez, Maria Soledad
Polo, Luis Mariano
author_facet Masone, Diego
Alvarez, Maria Soledad
Polo, Luis Mariano
author_sort Masone, Diego
collection PubMed
description Mutation landscapes and signatures have been thoroughly studied in SARS-CoV-2. Here, we analyse those patterns and link their changes to the viral replication tissue in the respiratory tract. Surprisingly, a substantial difference in those patterns is observed in samples from vaccinated patients. Hence, we propose a model to explain where those mutations could originate during the replication cycle.
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spelling pubmed-102808022023-06-21 The SARS-CoV-2 mutation landscape is shaped before replication starts Masone, Diego Alvarez, Maria Soledad Polo, Luis Mariano Genet Mol Biol Genomics and Bioinformatics Mutation landscapes and signatures have been thoroughly studied in SARS-CoV-2. Here, we analyse those patterns and link their changes to the viral replication tissue in the respiratory tract. Surprisingly, a substantial difference in those patterns is observed in samples from vaccinated patients. Hence, we propose a model to explain where those mutations could originate during the replication cycle. Sociedade Brasileira de Genética 2023-06-19 /pmc/articles/PMC10280802/ /pubmed/37338301 http://dx.doi.org/10.1590/1678-4685-GMB-2023-0005 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Genomics and Bioinformatics
Masone, Diego
Alvarez, Maria Soledad
Polo, Luis Mariano
The SARS-CoV-2 mutation landscape is shaped before replication starts
title The SARS-CoV-2 mutation landscape is shaped before replication starts
title_full The SARS-CoV-2 mutation landscape is shaped before replication starts
title_fullStr The SARS-CoV-2 mutation landscape is shaped before replication starts
title_full_unstemmed The SARS-CoV-2 mutation landscape is shaped before replication starts
title_short The SARS-CoV-2 mutation landscape is shaped before replication starts
title_sort sars-cov-2 mutation landscape is shaped before replication starts
topic Genomics and Bioinformatics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280802/
https://www.ncbi.nlm.nih.gov/pubmed/37338301
http://dx.doi.org/10.1590/1678-4685-GMB-2023-0005
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