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Inhibition of the MEK/ERK pathway suppresses immune overactivation and mitigates TDP-43 toxicity in a Drosophila model of ALS

TDP-43 is an important DNA/RNA-binding protein that is associated with age-related neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD); however, its pathomechanism is not fully understood. In a transgenic RNAi screen using Drosophila as a model, w...

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Detalles Bibliográficos
Autores principales:	Yue, Wenkai, Deng, Xue, Wang, Zhao, Jiang, Mingsheng, Hu, Rirong, Duan, Yongjia, Wang, Qiangqiang, Cui, Jihong, Fang, Yanshan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280928/ https://www.ncbi.nlm.nih.gov/pubmed/37340309 http://dx.doi.org/10.1186/s12979-023-00354-8

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