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Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy

Apolipoprotein (APOE) E4 isoform is a major risk factor of Alzheimer’s disease and contributes to metabolic and neuropathological abnormalities during brain aging. To provide insights into whether APOE4 genotype is related to tau-associated neurodegeneration, we have generated human P301S mutant tau...

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Detalles Bibliográficos
Autores principales:	Williams, Tristan, Bathe, Tim, Vo, Quan, Sacilotto, Patricia, McFarland, Karen, Ruiz, Alejandra Jolie, Hery, Gabriela P., Sullivan, Patrick, Borchelt, David R., Prokop, Stefan, Chakrabarty, Paramita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280946/ https://www.ncbi.nlm.nih.gov/pubmed/37337279 http://dx.doi.org/10.1186/s40478-023-01581-2

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