Cargando…

Survival status and predictors of mortality from severe community-acquired pneumonia among under-five children admitted at Debre Tabor comprehensive specialized hospital: a prospective cohort study

BACKGROUND: Globally, Pneumonia continues to be the leading cause of mortality among under-five children. Ethiopia ranks fourth out of 15 countries worldwide in terms of the highest death rate of under-five children due to severe community-acquired pneumonia (SCAP). However, to date, there is no rec...

Descripción completa

Detalles Bibliográficos
Autores principales: Kassaw, Amare, Kerebih, Gashaw, Zeleke, Shegaw, Chanie, Ermias Sisay, Dessalegn, Nigatu, Bante, Berihun, Teshome, Asefa Ageghehu, Chekole, Bogale, Gelaw, Belete, Bayih, Wubet Alebachew, Tesfaw, Aragaw, Feleke, Dejen Getaneh, Kefale, Demewoz, Azmeraw, Molla, Chanie, Aynadis, Awoke, Getaneh, Moges, Natnael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280987/
https://www.ncbi.nlm.nih.gov/pubmed/37346893
http://dx.doi.org/10.3389/fped.2023.1141366
_version_ 1785060920377999360
author Kassaw, Amare
Kerebih, Gashaw
Zeleke, Shegaw
Chanie, Ermias Sisay
Dessalegn, Nigatu
Bante, Berihun
Teshome, Asefa Ageghehu
Chekole, Bogale
Gelaw, Belete
Bayih, Wubet Alebachew
Tesfaw, Aragaw
Feleke, Dejen Getaneh
Kefale, Demewoz
Azmeraw, Molla
Chanie, Aynadis
Awoke, Getaneh
Moges, Natnael
author_facet Kassaw, Amare
Kerebih, Gashaw
Zeleke, Shegaw
Chanie, Ermias Sisay
Dessalegn, Nigatu
Bante, Berihun
Teshome, Asefa Ageghehu
Chekole, Bogale
Gelaw, Belete
Bayih, Wubet Alebachew
Tesfaw, Aragaw
Feleke, Dejen Getaneh
Kefale, Demewoz
Azmeraw, Molla
Chanie, Aynadis
Awoke, Getaneh
Moges, Natnael
author_sort Kassaw, Amare
collection PubMed
description BACKGROUND: Globally, Pneumonia continues to be the leading cause of mortality among under-five children. Ethiopia ranks fourth out of 15 countries worldwide in terms of the highest death rate of under-five children due to severe community-acquired pneumonia (SCAP). However, to date, there is no recent study that shows survival status and predictors of mortality from SCAP. Therefore, this study aimed to determine survival status and predictors of mortality from this dangerous disease among under-five children. METHODS: A facility-based prospective cohort study was conducted from 1 November 2021 to 31 October 2022 at Debre Tabor comprehensive specialized hospital. All under-five children with SCAP admitted during the study period were included. Participants were selected using a systematic sampling technique. The collected data were coded, edited, and entered into epi-data version 4.2 and then exported to STATA version 17 for further analysis. The Kaplan Meier failure estimate with log-rank test was employed to determine the survival estimates. A cox-proportional hazard regression model was fitted to identify significant variables. RESULTS: The overall incidence density rate of mortality was 5.7 /1000 children with a median hospital stay of 8.2 days. Heart disease (AHR: 4.37; 95%CI: 1.68–11.32), previous admission of SCAP (AHR: 3.87; 95% CI: 1.31–11.43), WFL < −3Z score (AHR: 3.57; 95% CI: 1.02–12.42), impaired consciousness level at admission 3.41(1.14–10.19), and pleural effusion (AHR: 3.42; 95%CI: 1.18–9.93) were significant predictors of mortality. CONCLUSION: In this study, the survival probability of children with SCAP was low. Children with heart disease, previous admission of SCAP, WFL < −3Z score, impaired consciousness level at admission, and pleural effusion had low survival. Therefore, much emphasis is needed on children with SCAP, particularly those with identified predictors.
format Online
Article
Text
id pubmed-10280987
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-102809872023-06-21 Survival status and predictors of mortality from severe community-acquired pneumonia among under-five children admitted at Debre Tabor comprehensive specialized hospital: a prospective cohort study Kassaw, Amare Kerebih, Gashaw Zeleke, Shegaw Chanie, Ermias Sisay Dessalegn, Nigatu Bante, Berihun Teshome, Asefa Ageghehu Chekole, Bogale Gelaw, Belete Bayih, Wubet Alebachew Tesfaw, Aragaw Feleke, Dejen Getaneh Kefale, Demewoz Azmeraw, Molla Chanie, Aynadis Awoke, Getaneh Moges, Natnael Front Pediatr Pediatrics BACKGROUND: Globally, Pneumonia continues to be the leading cause of mortality among under-five children. Ethiopia ranks fourth out of 15 countries worldwide in terms of the highest death rate of under-five children due to severe community-acquired pneumonia (SCAP). However, to date, there is no recent study that shows survival status and predictors of mortality from SCAP. Therefore, this study aimed to determine survival status and predictors of mortality from this dangerous disease among under-five children. METHODS: A facility-based prospective cohort study was conducted from 1 November 2021 to 31 October 2022 at Debre Tabor comprehensive specialized hospital. All under-five children with SCAP admitted during the study period were included. Participants were selected using a systematic sampling technique. The collected data were coded, edited, and entered into epi-data version 4.2 and then exported to STATA version 17 for further analysis. The Kaplan Meier failure estimate with log-rank test was employed to determine the survival estimates. A cox-proportional hazard regression model was fitted to identify significant variables. RESULTS: The overall incidence density rate of mortality was 5.7 /1000 children with a median hospital stay of 8.2 days. Heart disease (AHR: 4.37; 95%CI: 1.68–11.32), previous admission of SCAP (AHR: 3.87; 95% CI: 1.31–11.43), WFL < −3Z score (AHR: 3.57; 95% CI: 1.02–12.42), impaired consciousness level at admission 3.41(1.14–10.19), and pleural effusion (AHR: 3.42; 95%CI: 1.18–9.93) were significant predictors of mortality. CONCLUSION: In this study, the survival probability of children with SCAP was low. Children with heart disease, previous admission of SCAP, WFL < −3Z score, impaired consciousness level at admission, and pleural effusion had low survival. Therefore, much emphasis is needed on children with SCAP, particularly those with identified predictors. Frontiers Media S.A. 2023-06-05 /pmc/articles/PMC10280987/ /pubmed/37346893 http://dx.doi.org/10.3389/fped.2023.1141366 Text en © 2023 Kassaw, Kerebih, Zeleke, Chanie, Desalegn, Bante, Teshome, Chekole, Gelaw, Bayih, Tesfaw, Feleke, Kefale, Azmeraw, Chanie, Awoke and Moges. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Kassaw, Amare
Kerebih, Gashaw
Zeleke, Shegaw
Chanie, Ermias Sisay
Dessalegn, Nigatu
Bante, Berihun
Teshome, Asefa Ageghehu
Chekole, Bogale
Gelaw, Belete
Bayih, Wubet Alebachew
Tesfaw, Aragaw
Feleke, Dejen Getaneh
Kefale, Demewoz
Azmeraw, Molla
Chanie, Aynadis
Awoke, Getaneh
Moges, Natnael
Survival status and predictors of mortality from severe community-acquired pneumonia among under-five children admitted at Debre Tabor comprehensive specialized hospital: a prospective cohort study
title Survival status and predictors of mortality from severe community-acquired pneumonia among under-five children admitted at Debre Tabor comprehensive specialized hospital: a prospective cohort study
title_full Survival status and predictors of mortality from severe community-acquired pneumonia among under-five children admitted at Debre Tabor comprehensive specialized hospital: a prospective cohort study
title_fullStr Survival status and predictors of mortality from severe community-acquired pneumonia among under-five children admitted at Debre Tabor comprehensive specialized hospital: a prospective cohort study
title_full_unstemmed Survival status and predictors of mortality from severe community-acquired pneumonia among under-five children admitted at Debre Tabor comprehensive specialized hospital: a prospective cohort study
title_short Survival status and predictors of mortality from severe community-acquired pneumonia among under-five children admitted at Debre Tabor comprehensive specialized hospital: a prospective cohort study
title_sort survival status and predictors of mortality from severe community-acquired pneumonia among under-five children admitted at debre tabor comprehensive specialized hospital: a prospective cohort study
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280987/
https://www.ncbi.nlm.nih.gov/pubmed/37346893
http://dx.doi.org/10.3389/fped.2023.1141366
work_keys_str_mv AT kassawamare survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy
AT kerebihgashaw survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy
AT zelekeshegaw survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy
AT chanieermiassisay survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy
AT dessalegnnigatu survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy
AT banteberihun survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy
AT teshomeasefaageghehu survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy
AT chekolebogale survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy
AT gelawbelete survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy
AT bayihwubetalebachew survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy
AT tesfawaragaw survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy
AT felekedejengetaneh survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy
AT kefaledemewoz survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy
AT azmerawmolla survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy
AT chanieaynadis survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy
AT awokegetaneh survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy
AT mogesnatnael survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy