Cargando…
Survival status and predictors of mortality from severe community-acquired pneumonia among under-five children admitted at Debre Tabor comprehensive specialized hospital: a prospective cohort study
BACKGROUND: Globally, Pneumonia continues to be the leading cause of mortality among under-five children. Ethiopia ranks fourth out of 15 countries worldwide in terms of the highest death rate of under-five children due to severe community-acquired pneumonia (SCAP). However, to date, there is no rec...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280987/ https://www.ncbi.nlm.nih.gov/pubmed/37346893 http://dx.doi.org/10.3389/fped.2023.1141366 |
_version_ | 1785060920377999360 |
---|---|
author | Kassaw, Amare Kerebih, Gashaw Zeleke, Shegaw Chanie, Ermias Sisay Dessalegn, Nigatu Bante, Berihun Teshome, Asefa Ageghehu Chekole, Bogale Gelaw, Belete Bayih, Wubet Alebachew Tesfaw, Aragaw Feleke, Dejen Getaneh Kefale, Demewoz Azmeraw, Molla Chanie, Aynadis Awoke, Getaneh Moges, Natnael |
author_facet | Kassaw, Amare Kerebih, Gashaw Zeleke, Shegaw Chanie, Ermias Sisay Dessalegn, Nigatu Bante, Berihun Teshome, Asefa Ageghehu Chekole, Bogale Gelaw, Belete Bayih, Wubet Alebachew Tesfaw, Aragaw Feleke, Dejen Getaneh Kefale, Demewoz Azmeraw, Molla Chanie, Aynadis Awoke, Getaneh Moges, Natnael |
author_sort | Kassaw, Amare |
collection | PubMed |
description | BACKGROUND: Globally, Pneumonia continues to be the leading cause of mortality among under-five children. Ethiopia ranks fourth out of 15 countries worldwide in terms of the highest death rate of under-five children due to severe community-acquired pneumonia (SCAP). However, to date, there is no recent study that shows survival status and predictors of mortality from SCAP. Therefore, this study aimed to determine survival status and predictors of mortality from this dangerous disease among under-five children. METHODS: A facility-based prospective cohort study was conducted from 1 November 2021 to 31 October 2022 at Debre Tabor comprehensive specialized hospital. All under-five children with SCAP admitted during the study period were included. Participants were selected using a systematic sampling technique. The collected data were coded, edited, and entered into epi-data version 4.2 and then exported to STATA version 17 for further analysis. The Kaplan Meier failure estimate with log-rank test was employed to determine the survival estimates. A cox-proportional hazard regression model was fitted to identify significant variables. RESULTS: The overall incidence density rate of mortality was 5.7 /1000 children with a median hospital stay of 8.2 days. Heart disease (AHR: 4.37; 95%CI: 1.68–11.32), previous admission of SCAP (AHR: 3.87; 95% CI: 1.31–11.43), WFL < −3Z score (AHR: 3.57; 95% CI: 1.02–12.42), impaired consciousness level at admission 3.41(1.14–10.19), and pleural effusion (AHR: 3.42; 95%CI: 1.18–9.93) were significant predictors of mortality. CONCLUSION: In this study, the survival probability of children with SCAP was low. Children with heart disease, previous admission of SCAP, WFL < −3Z score, impaired consciousness level at admission, and pleural effusion had low survival. Therefore, much emphasis is needed on children with SCAP, particularly those with identified predictors. |
format | Online Article Text |
id | pubmed-10280987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102809872023-06-21 Survival status and predictors of mortality from severe community-acquired pneumonia among under-five children admitted at Debre Tabor comprehensive specialized hospital: a prospective cohort study Kassaw, Amare Kerebih, Gashaw Zeleke, Shegaw Chanie, Ermias Sisay Dessalegn, Nigatu Bante, Berihun Teshome, Asefa Ageghehu Chekole, Bogale Gelaw, Belete Bayih, Wubet Alebachew Tesfaw, Aragaw Feleke, Dejen Getaneh Kefale, Demewoz Azmeraw, Molla Chanie, Aynadis Awoke, Getaneh Moges, Natnael Front Pediatr Pediatrics BACKGROUND: Globally, Pneumonia continues to be the leading cause of mortality among under-five children. Ethiopia ranks fourth out of 15 countries worldwide in terms of the highest death rate of under-five children due to severe community-acquired pneumonia (SCAP). However, to date, there is no recent study that shows survival status and predictors of mortality from SCAP. Therefore, this study aimed to determine survival status and predictors of mortality from this dangerous disease among under-five children. METHODS: A facility-based prospective cohort study was conducted from 1 November 2021 to 31 October 2022 at Debre Tabor comprehensive specialized hospital. All under-five children with SCAP admitted during the study period were included. Participants were selected using a systematic sampling technique. The collected data were coded, edited, and entered into epi-data version 4.2 and then exported to STATA version 17 for further analysis. The Kaplan Meier failure estimate with log-rank test was employed to determine the survival estimates. A cox-proportional hazard regression model was fitted to identify significant variables. RESULTS: The overall incidence density rate of mortality was 5.7 /1000 children with a median hospital stay of 8.2 days. Heart disease (AHR: 4.37; 95%CI: 1.68–11.32), previous admission of SCAP (AHR: 3.87; 95% CI: 1.31–11.43), WFL < −3Z score (AHR: 3.57; 95% CI: 1.02–12.42), impaired consciousness level at admission 3.41(1.14–10.19), and pleural effusion (AHR: 3.42; 95%CI: 1.18–9.93) were significant predictors of mortality. CONCLUSION: In this study, the survival probability of children with SCAP was low. Children with heart disease, previous admission of SCAP, WFL < −3Z score, impaired consciousness level at admission, and pleural effusion had low survival. Therefore, much emphasis is needed on children with SCAP, particularly those with identified predictors. Frontiers Media S.A. 2023-06-05 /pmc/articles/PMC10280987/ /pubmed/37346893 http://dx.doi.org/10.3389/fped.2023.1141366 Text en © 2023 Kassaw, Kerebih, Zeleke, Chanie, Desalegn, Bante, Teshome, Chekole, Gelaw, Bayih, Tesfaw, Feleke, Kefale, Azmeraw, Chanie, Awoke and Moges. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Kassaw, Amare Kerebih, Gashaw Zeleke, Shegaw Chanie, Ermias Sisay Dessalegn, Nigatu Bante, Berihun Teshome, Asefa Ageghehu Chekole, Bogale Gelaw, Belete Bayih, Wubet Alebachew Tesfaw, Aragaw Feleke, Dejen Getaneh Kefale, Demewoz Azmeraw, Molla Chanie, Aynadis Awoke, Getaneh Moges, Natnael Survival status and predictors of mortality from severe community-acquired pneumonia among under-five children admitted at Debre Tabor comprehensive specialized hospital: a prospective cohort study |
title | Survival status and predictors of mortality from severe community-acquired pneumonia among under-five children admitted at Debre Tabor comprehensive specialized hospital: a prospective cohort study |
title_full | Survival status and predictors of mortality from severe community-acquired pneumonia among under-five children admitted at Debre Tabor comprehensive specialized hospital: a prospective cohort study |
title_fullStr | Survival status and predictors of mortality from severe community-acquired pneumonia among under-five children admitted at Debre Tabor comprehensive specialized hospital: a prospective cohort study |
title_full_unstemmed | Survival status and predictors of mortality from severe community-acquired pneumonia among under-five children admitted at Debre Tabor comprehensive specialized hospital: a prospective cohort study |
title_short | Survival status and predictors of mortality from severe community-acquired pneumonia among under-five children admitted at Debre Tabor comprehensive specialized hospital: a prospective cohort study |
title_sort | survival status and predictors of mortality from severe community-acquired pneumonia among under-five children admitted at debre tabor comprehensive specialized hospital: a prospective cohort study |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10280987/ https://www.ncbi.nlm.nih.gov/pubmed/37346893 http://dx.doi.org/10.3389/fped.2023.1141366 |
work_keys_str_mv | AT kassawamare survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy AT kerebihgashaw survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy AT zelekeshegaw survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy AT chanieermiassisay survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy AT dessalegnnigatu survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy AT banteberihun survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy AT teshomeasefaageghehu survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy AT chekolebogale survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy AT gelawbelete survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy AT bayihwubetalebachew survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy AT tesfawaragaw survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy AT felekedejengetaneh survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy AT kefaledemewoz survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy AT azmerawmolla survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy AT chanieaynadis survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy AT awokegetaneh survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy AT mogesnatnael survivalstatusandpredictorsofmortalityfromseverecommunityacquiredpneumoniaamongunderfivechildrenadmittedatdebretaborcomprehensivespecializedhospitalaprospectivecohortstudy |