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Potential utility of urinary chemokine CCL2 to creatinine ratio in prognosis of 5‐year graft failure and mortality post 1‐year protocol biopsy in kidney transplant recipients

BACKGROUND: Chemokines (chemotactic cytokines) are small proteins which are engaged in many pathophysiological processes, including inflammation and homeostasis. In recent years, application of chemokines in transplant medicine was intensively studied. The aim of this study was to determine the util...

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Autores principales: Gniewkiewicz, Michal, Gozdowska, Jolanta, Deborska‐Materkowska, Dominika, Czerwinska, Katarzyna, Perkowska‐Ptasinska, Agnieszka, Burban, Anna, Cieslik, Aleksandra, Kosieradzki, Maciej, Durlik, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10281015/
https://www.ncbi.nlm.nih.gov/pubmed/37382267
http://dx.doi.org/10.1002/iid3.901
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author Gniewkiewicz, Michal
Gozdowska, Jolanta
Deborska‐Materkowska, Dominika
Czerwinska, Katarzyna
Perkowska‐Ptasinska, Agnieszka
Burban, Anna
Cieslik, Aleksandra
Kosieradzki, Maciej
Durlik, Magdalena
author_facet Gniewkiewicz, Michal
Gozdowska, Jolanta
Deborska‐Materkowska, Dominika
Czerwinska, Katarzyna
Perkowska‐Ptasinska, Agnieszka
Burban, Anna
Cieslik, Aleksandra
Kosieradzki, Maciej
Durlik, Magdalena
author_sort Gniewkiewicz, Michal
collection PubMed
description BACKGROUND: Chemokines (chemotactic cytokines) are small proteins which are engaged in many pathophysiological processes, including inflammation and homeostasis. In recent years, application of chemokines in transplant medicine was intensively studied. The aim of this study was to determine the utility of urinary chemokines CCL2 (C‐C motif ligand 2) and CXCL10 (C‐X‐C motif chemokine ligand 10) in prognosis of 5‐year graft failure and mortality post 1‐year protocol biopsy in renal transplant recipients. METHODS: Forty patients who had a protocol biopsy 1 year after renal transplantation were included. Concentrations of CCL2 and CXCL10 in urine with reference to urine creatinine were measured. All patients were under the supervision of one transplant center. Long‐term outcomes within 5 years after 1‐year posttransplant biopsy were analyzed. RESULTS: Urinary CCL2:Cr at the time of biopsy was significantly increased in patients who died or had graft failure. CCL2:Cr was proven to be a significant predictor of 5‐year graft failure and mortality (odds ratio [OR]: 1.09, 95% confidence interval [CI]: 1.02–1.19, p = .02; OR: 1.08, 95% CI: 1.02–1.16, p = .04; respectively). CONCLUSION: Chemokines are easily detected by current methods. In the era of personalized medicine, urinary CCL2:Cr can be considered as a factor providing complementary information regarding risk of graft failure or increased mortality.
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spelling pubmed-102810152023-06-21 Potential utility of urinary chemokine CCL2 to creatinine ratio in prognosis of 5‐year graft failure and mortality post 1‐year protocol biopsy in kidney transplant recipients Gniewkiewicz, Michal Gozdowska, Jolanta Deborska‐Materkowska, Dominika Czerwinska, Katarzyna Perkowska‐Ptasinska, Agnieszka Burban, Anna Cieslik, Aleksandra Kosieradzki, Maciej Durlik, Magdalena Immun Inflamm Dis Original Articles BACKGROUND: Chemokines (chemotactic cytokines) are small proteins which are engaged in many pathophysiological processes, including inflammation and homeostasis. In recent years, application of chemokines in transplant medicine was intensively studied. The aim of this study was to determine the utility of urinary chemokines CCL2 (C‐C motif ligand 2) and CXCL10 (C‐X‐C motif chemokine ligand 10) in prognosis of 5‐year graft failure and mortality post 1‐year protocol biopsy in renal transplant recipients. METHODS: Forty patients who had a protocol biopsy 1 year after renal transplantation were included. Concentrations of CCL2 and CXCL10 in urine with reference to urine creatinine were measured. All patients were under the supervision of one transplant center. Long‐term outcomes within 5 years after 1‐year posttransplant biopsy were analyzed. RESULTS: Urinary CCL2:Cr at the time of biopsy was significantly increased in patients who died or had graft failure. CCL2:Cr was proven to be a significant predictor of 5‐year graft failure and mortality (odds ratio [OR]: 1.09, 95% confidence interval [CI]: 1.02–1.19, p = .02; OR: 1.08, 95% CI: 1.02–1.16, p = .04; respectively). CONCLUSION: Chemokines are easily detected by current methods. In the era of personalized medicine, urinary CCL2:Cr can be considered as a factor providing complementary information regarding risk of graft failure or increased mortality. John Wiley and Sons Inc. 2023-06-20 /pmc/articles/PMC10281015/ /pubmed/37382267 http://dx.doi.org/10.1002/iid3.901 Text en © 2023 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Gniewkiewicz, Michal
Gozdowska, Jolanta
Deborska‐Materkowska, Dominika
Czerwinska, Katarzyna
Perkowska‐Ptasinska, Agnieszka
Burban, Anna
Cieslik, Aleksandra
Kosieradzki, Maciej
Durlik, Magdalena
Potential utility of urinary chemokine CCL2 to creatinine ratio in prognosis of 5‐year graft failure and mortality post 1‐year protocol biopsy in kidney transplant recipients
title Potential utility of urinary chemokine CCL2 to creatinine ratio in prognosis of 5‐year graft failure and mortality post 1‐year protocol biopsy in kidney transplant recipients
title_full Potential utility of urinary chemokine CCL2 to creatinine ratio in prognosis of 5‐year graft failure and mortality post 1‐year protocol biopsy in kidney transplant recipients
title_fullStr Potential utility of urinary chemokine CCL2 to creatinine ratio in prognosis of 5‐year graft failure and mortality post 1‐year protocol biopsy in kidney transplant recipients
title_full_unstemmed Potential utility of urinary chemokine CCL2 to creatinine ratio in prognosis of 5‐year graft failure and mortality post 1‐year protocol biopsy in kidney transplant recipients
title_short Potential utility of urinary chemokine CCL2 to creatinine ratio in prognosis of 5‐year graft failure and mortality post 1‐year protocol biopsy in kidney transplant recipients
title_sort potential utility of urinary chemokine ccl2 to creatinine ratio in prognosis of 5‐year graft failure and mortality post 1‐year protocol biopsy in kidney transplant recipients
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10281015/
https://www.ncbi.nlm.nih.gov/pubmed/37382267
http://dx.doi.org/10.1002/iid3.901
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