Immunogenicity and safety of heterologous immunisation with Ad5-nCOV in healthy adults aged 60 years and older primed with an inactivated SARS-CoV-2 vaccine (CoronaVac): a phase 4, randomised, observer-blind, non-inferiority trial

BACKGROUND: People over 60 have been found to develop less protection after two doses of inactivated COVID-19 vaccines than younger people. Heterologous immunisation could potentially induce more robust immune responses compared to homologous immunisation. We aimed to assess the immunogenicity and s...

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Detalles Bibliográficos
Autores principales: Jin, Peng-Fei, Guo, Xi-Ling, Gou, Jin-Bo, Hou, Li-Hua, Song, Zhi-Zhou, Zhu, Tao, Pan, Hong-Xing, Zhu, Jia-Hong, Shi, Feng-Juan, Du, Pan, Huang, Hai-Tao, Liu, Jing-Xian, Zheng, Hui, Wang, Xue, Chen, Yin, Wan, Peng, Wu, Shi-Po, Wang, Xue-Wen, Xu, Xiao-Yu, Yan, Fang-Rong, Li, Jing-Xin, Chen, Wei, Zhu, Feng-Cai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10281458/
https://www.ncbi.nlm.nih.gov/pubmed/37360864
http://dx.doi.org/10.1016/j.lanwpc.2023.100829

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