The engineered CRISPR‐Mb2Cas12a variant enables sensitive and fast nucleic acid‐based pathogens diagnostics in the field

Existing CRISPR/Cas12a‐based diagnostic platforms offer accurate and vigorous monitoring of nucleic acid targets, but have the potential to be further optimized for more efficient detection. Here, we profiled 16 Cas12a orthologs, focusing on their trans‐cleavage activity and their potential as diagn...

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Detalles Bibliográficos
Autores principales: Jiao, Jian, Liu, Yiqi, Yang, Mengli, Zheng, Jingcheng, Liu, Chonghuai, Ye, Wenxiu, Song, Shangwei, Bai, Tuanhui, Song, Chunhui, Wang, Miaomiao, Shi, Jiangli, Wan, Ran, Zhang, Kunxi, Hao, Pengbo, Feng, Jiancan, Zheng, Xianbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10281610/
https://www.ncbi.nlm.nih.gov/pubmed/37069831
http://dx.doi.org/10.1111/pbi.14051

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