Resveratrol stimulates StAR expression and progesterone production by GPER-mediated downregulation of Snail expression in human granulosa cells

Steroidogenic acute regulatory protein (StAR) plays a critical role in the regulation of progesterone (P4) production. Resveratrol (RSV), a natural polyphenol, has beneficial effects on reproductive function. However, its effects on StAR expression and P4 production in human granulosa cells remain u...

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Detalles Bibliográficos
Autores principales: Song, Tinglin, Chen, Jiaye, Yang, Sizhu, Liu, Boqun, Zhang, Lingling, Zhang, Qian, Cheng, Jung-Chien, Fang, Lanlan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taiwan Food and Drug Administration 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10281732/
https://www.ncbi.nlm.nih.gov/pubmed/37335164
http://dx.doi.org/10.38212/2224-6614.3460
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author Song, Tinglin
Chen, Jiaye
Yang, Sizhu
Liu, Boqun
Zhang, Lingling
Zhang, Qian
Cheng, Jung-Chien
Fang, Lanlan
author_facet Song, Tinglin
Chen, Jiaye
Yang, Sizhu
Liu, Boqun
Zhang, Lingling
Zhang, Qian
Cheng, Jung-Chien
Fang, Lanlan
author_sort Song, Tinglin
collection PubMed
description Steroidogenic acute regulatory protein (StAR) plays a critical role in the regulation of progesterone (P4) production. Resveratrol (RSV), a natural polyphenol, has beneficial effects on reproductive function. However, its effects on StAR expression and P4 production in human granulosa cells remain undetermined. In this study, we showed that treatment of RSV upregulated StAR expression in human granulosa cells. G protein-coupled estrogen receptor (GPER) and ERK1/2 signaling were involved in RSV-stimulated StAR expression and P4 production. In addition, the expression of a transcriptional repressor, Snail, was downregulated by RSV, which contributed to the RSV-induced inductions of StAR expression and P4 production.
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spelling pubmed-102817322023-06-21 Resveratrol stimulates StAR expression and progesterone production by GPER-mediated downregulation of Snail expression in human granulosa cells Song, Tinglin Chen, Jiaye Yang, Sizhu Liu, Boqun Zhang, Lingling Zhang, Qian Cheng, Jung-Chien Fang, Lanlan J Food Drug Anal Original Article Steroidogenic acute regulatory protein (StAR) plays a critical role in the regulation of progesterone (P4) production. Resveratrol (RSV), a natural polyphenol, has beneficial effects on reproductive function. However, its effects on StAR expression and P4 production in human granulosa cells remain undetermined. In this study, we showed that treatment of RSV upregulated StAR expression in human granulosa cells. G protein-coupled estrogen receptor (GPER) and ERK1/2 signaling were involved in RSV-stimulated StAR expression and P4 production. In addition, the expression of a transcriptional repressor, Snail, was downregulated by RSV, which contributed to the RSV-induced inductions of StAR expression and P4 production. Taiwan Food and Drug Administration 2023-06-15 /pmc/articles/PMC10281732/ /pubmed/37335164 http://dx.doi.org/10.38212/2224-6614.3460 Text en © 2023 Taiwan Food and Drug Administration https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Original Article
Song, Tinglin
Chen, Jiaye
Yang, Sizhu
Liu, Boqun
Zhang, Lingling
Zhang, Qian
Cheng, Jung-Chien
Fang, Lanlan
Resveratrol stimulates StAR expression and progesterone production by GPER-mediated downregulation of Snail expression in human granulosa cells
title Resveratrol stimulates StAR expression and progesterone production by GPER-mediated downregulation of Snail expression in human granulosa cells
title_full Resveratrol stimulates StAR expression and progesterone production by GPER-mediated downregulation of Snail expression in human granulosa cells
title_fullStr Resveratrol stimulates StAR expression and progesterone production by GPER-mediated downregulation of Snail expression in human granulosa cells
title_full_unstemmed Resveratrol stimulates StAR expression and progesterone production by GPER-mediated downregulation of Snail expression in human granulosa cells
title_short Resveratrol stimulates StAR expression and progesterone production by GPER-mediated downregulation of Snail expression in human granulosa cells
title_sort resveratrol stimulates star expression and progesterone production by gper-mediated downregulation of snail expression in human granulosa cells
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10281732/
https://www.ncbi.nlm.nih.gov/pubmed/37335164
http://dx.doi.org/10.38212/2224-6614.3460
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