The FBXO32/ATR/ATM axis acts as a molecular switch to control the sensitivity of osteosarcoma cells to irradiation through its regulation of EXO1 expression: FBXO32/ATR/ATM/EXO1 axis induces OS cells to anti-radiotherapy

Osteosarcoma (OS) is the most common primary bone cancer in children and adolescents. In clinical treatments, the insensitivity of OS to conventional radiotherapy regimens significantly contributes to poor patient prognosis and survival. EXO1 is responsible for DNA repair pathways and telomere maint...

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Detalles Bibliográficos
Autores principales: Lu, Yao, Huang, Panpan, Li, Yanli, Liu, Wenyu, Li, Jing, Zhao, Rui, Feng, Haihua, Shi, Ce, Cao, Gaolu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10281878/
https://www.ncbi.nlm.nih.gov/pubmed/37227155
http://dx.doi.org/10.3724/abbs.2023049

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