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Rosuvastatin suppresses TNF-α-induced matrix catabolism, pyroptosis and senescence via the HMGB1/NF-κB signaling pathway in nucleus pulposus cells: Role of rosuvastatin in alleviating intervertebral disc degeneration

Intervertebral disc degeneration is mainly caused by irregular matrix metabolism in nucleus pulposus cells and involves inflammatory factors such as TNF-α. Rosuvastatin, which is widely used in the clinic to reduce cholesterol levels, exerts anti-inflammatory effects, but whether rosuvastatin partic...

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Detalles Bibliográficos
Autores principales:	Chen, Weijian, Deng, Zhihuai, Zhu, Jianxiong, Yuan, Liang, Li, Shuangxing, Zhang, Yangyang, Wu, Jiajun, Huang, Zhengqi, Qin, Tianyu, Ye, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Science Press 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10281883/ https://www.ncbi.nlm.nih.gov/pubmed/37222533 http://dx.doi.org/10.3724/abbs.2023026

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