Cargando…

Blood-brain barrier disruption defines the extracellular metabolome of live human high-grade gliomas

The extracellular microenvironment modulates glioma behaviour. It remains unknown if blood-brain barrier disruption merely reflects or functionally supports glioma aggressiveness. We utilised intra-operative microdialysis to sample the extracellular metabolome of radiographically diverse regions of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Riviere-Cazaux, Cecile, Carlstrom, Lucas P., Rajani, Karishma, Munoz-Casabella, Amanda, Rahman, Masum, Gharibi-Loron, Ali, Brown, Desmond A., Miller, Kai J., White, Jaclyn J., Himes, Benjamin T., Jusue-Torres, Ignacio, Ikram, Samar, Ransom, Seth C., Hirte, Renee, Oh, Ju-Hee, Elmquist, William F., Sarkaria, Jann N., Vaubel, Rachael A., Rodriguez, Moses, Warrington, Arthur E., Kizilbash, Sani H., Burns, Terry C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10281947/ https://www.ncbi.nlm.nih.gov/pubmed/37340056 http://dx.doi.org/10.1038/s42003-023-05035-2

Ejemplares similares

DDRE-12. HETEROGENOUS RESPONSE OF IDH-MUTANT AND IDH-WT GLIOMA TO NAMPT INHIBITION
por: Rahman, Masum, et al.
Publicado: (2021)

CLRM-14 INTRATUMORAL EXTRACELLULAR METABOLIC IMPACT OF DFMO AND AMXT 1501 IN LIVE HUMAN GLIOMAS
por: Riviere-Cazaux, Cecile, et al.
Publicado: (2022)

An untapped window of opportunity for glioma: targeting therapy-induced senescence prior to recurrence
por: Riviere-Cazaux, Cecile, et al.
Publicado: (2023)

BIMG-20. METABOLIC BIOMARKERS IN MICRODIALYSATE OF IDH-1 MUTANT TUMORS
por: Rajani, Karishma, et al.
Publicado: (2021)

TIPS-07 LONGITUDINAL CSF PROTEOMICS FOR MONITORING AND PHARMACODYNAMIC BIOMARKER DISCOVERY
por: Riviere-Cazaux, Cecile, et al.
Publicado: (2023)

Cerebrospinal fluid 2-hydroxyglutarate as a monitoring biomarker for IDH-mutant gliomas
por: Riviere-Cazaux, Cecile, et al.
Publicado: (2023)

Editorial: Targeted Therapies for Glioblastoma: A Critical Appraisal
por: Gupta, Shiv K., et al.
Publicado: (2019)

Selective Vulnerability of Senescent Glioblastoma Cells to BCL-XL Inhibition
por: Rahman, Masum, et al.
Publicado: (2022)

TIPS-09 FIRST-IN-HUMAN PHASE 1 TRIAL OF THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PRELIMINARY ANTI-TUMOR ACTIVITY OF WSD0922-FU (NCT04197934): TRIAL IN PROGRESS
por: Kizilbash, Sani, et al.
Publicado: (2023)

PARP Inhibitors for Sensitization of Alkylation Chemotherapy in Glioblastoma: Impact of Blood-Brain Barrier and Molecular Heterogeneity
por: Gupta, Shiv K., et al.
Publicado: (2019)

Harnessing Radiation Biology to Augment Immunotherapy for Glioblastoma
por: Rajani, Karishma R., et al.
Publicado: (2019)

Evaluation of Complications after Surgical Treatment of Thoracic Outlet Syndrome
por: Hosseinian, Mohammad Ali, et al.
Publicado: (2017)

In silico Screening and Evaluation of the Anticonvulsant Activity of Docosahexaenoic Acid-Like Molecules in Experimental Models of Seizures
por: Loron, Ali Gharibi, et al.
Publicado: (2017)

Addressing BBB Heterogeneity: A New Paradigm for Drug Delivery to Brain Tumors
por: Griffith, Jessica I., et al.
Publicado: (2020)

SDPS-31 EXTRACELLULAR VESICLES AND THEIR CARGO AS A PHARMACODYNAMIC REPORTER IN GLIOBLASTOMA
por: DeLuca, Valerie, et al.
Publicado: (2023)

TRANSLATIONAL RESEARCH-03 MULTIPLE MECHANISMS MODULATE TEMOZOLOMIDE RESISTANCE AND ARE POTENTIAL TARGETS FOR GLIOBLASTOMA THERAPY.
por: Kitange, Gaspar, et al.
Publicado: (2023)

CLRM-13. INTRAOPERATIVE MICRODIALYSIS: GLIOMA INTELLIGENCE FROM BEHIND ENEMY LINES
por: Riviere-Cazaux, Cecile, et al.
Publicado: (2021)

THE FORM AND FUNCTION OF SYNOVIAL CELLS IN TISSUE CULTURES : II. THE PRODUCTION OF MUCIN
por: Vaubel, Ernst
Publicado: (1933)

THE FORM AND FUNCTION OF SYNOVIAL CELLS IN TISSUE CULTURES : I. MORPHOLOGY OF THE CELLS UNDER VARYING CONDITIONS
por: Vaubel, Ernst
Publicado: (1933)

Efficacy of (177)Lu-Dotatate Therapy in the Treatment of Recurrent Meningioma
por: Zahid, Anza, et al.
Publicado: (2021)

Enhancing Brain Retention of a KIF11 Inhibitor Significantly Improves its Efficacy in a Mouse Model of Glioblastoma
por: Gampa, Gautham, et al.
Publicado: (2020)

Characterization of relative biological effectiveness for conventional radiation therapy: a comparison of clinical 6 MV X-rays and (137)Cs
por: Howard, Michelle, et al.
Publicado: (2017)

Perivascular Stromal Cells Instruct Glioblastoma Invasion, Proliferation, and Therapeutic Response within an Engineered Brain Perivascular Niche Model
por: Ngo, Mai T., et al.
Publicado: (2022)

The role of CCR5 in HIV-associated neurocognitive disorders
por: Riviere-Cazaux, Cecile, et al.
Publicado: (2022)

HGG-10. Efficacy of convection-enhanced delivery of GB-13 (IL13.E13K-PE4E) in an orthotopic xenograft model of high-grade glioma is predicated on IL-13Rα2 expression.
por: Rechberger, Julian, et al.
Publicado: (2022)

Convertible MRI contrast: Sensing the delivery and release of anti-glioma nano-drugs
por: Zhang, Liang, et al.
Publicado: (2015)

Disparities in Reported Testing for 1p/19q Codeletion in Oligodendroglioma and Oligoastrocytoma Patients: An Analysis of the National Cancer Database
por: Zreik, Jad, et al.
Publicado: (2021)

Convection enhanced delivery of EGFR targeting antibody-drug conjugates Serclutamab talirine and Depatux-M in glioblastoma patient-derived xenografts
por: Porath, Kendra A, et al.
Publicado: (2022)

Peptide Carrier-Mediated Non-Covalent Delivery of Unmodified Cisplatin, Methotrexate and Other Agents via Intravenous Route to the Brain
por: Sarkar, Gobinda, et al.
Publicado: (2014)

MARQUIS: A Multiplex Method for Absolute Quantification of Peptides and Post-Translational Modifications
por: Curran, Timothy G, et al.
Publicado: (2015)

The efficacy of an unrestricted cycling ketogenic diet in preclinical models of IDH wild-type and IDH mutant glioma
por: Javier, Rodrigo, et al.
Publicado: (2022)

LOCL-07 LOCO-REGIONAL INFUSION OF GB-13 (IL13.E13K-PE4E) AS A POTENTIALLY PROMISING TREATMENT FOR RECURRENT HIGH-GRADE GLIOMA
por: Rechberger, Julian, et al.
Publicado: (2022)

Main Manuscript for Cell migration simulator-based biomarkers for glioblastoma
por: Hou, Jay, et al.
Publicado: (2023)

Quantifying Glioblastoma Drug Response Dynamics Incorporating Treatment Sensitivity and Blood Brain Barrier Penetrance From Experimental Data
por: Massey, Susan Christine, et al.
Publicado: (2020)

MDM2 Inhibition in the Treatment of Glioblastoma: From Concept to Clinical Investigation
por: Pellot Ortiz, Karolina I., et al.
Publicado: (2023)

P21 Overexpression Promotes Cell Death and Induces Senescence in Human Glioblastoma
por: Mansour, Moustafa A., et al.
Publicado: (2023)

VARYING INFLUENCE OF TUBERCULOUS RABBIT PLASMA ON THE GROWTH OF FIBROBLASTS IN VITRO
por: Swift, Homer F., et al.
Publicado: (1934)

A COMPARISON OF OCULAR MICROMETRIC AND PROJECTOSCOPIC METHODS OF ESTIMATING GROWTHS IN TISSUE CULTURES
por: Swift, Homer F., et al.
Publicado: (1934)

Mechanical complication of endobronchial tuberculosis
por: Kizilbash, Quratulain Fatima
Publicado: (2015)

Harnessing the Power of Onco-Immunotherapy with Checkpoint Inhibitors
por: Rajani, Karishma R., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_d9krlhpning52tdubl0mnc3eft